Sm proteins
E561090
Sm proteins are a family of small, evolutionarily conserved RNA-binding proteins that form the core of small nuclear ribonucleoproteins (snRNPs) essential for pre-mRNA splicing in eukaryotic cells.
All labels observed (3)
| Label | Occurrences |
|---|---|
| Sm proteins canonical | 3 |
| Sm core proteins | 1 |
| UNRIP protein | 1 |
How this entity was disambiguated
This entity first appeared as the object of triple T6004697 — resolving that mention is where its identity was fixed. The disambiguator weighed these candidate entities and picked the highlighted one (or “None”, minting a new entity). This is how homonymy is resolved: the same surface form can point to different entities.
NED1
Entity disambiguation (via context triple)
gpt-5-mini-2025-08-07
Target entity: Sm proteins Context triple: [Survival motor neuron protein, interactsWith, Sm proteins]
-
A.
Sm6
Sm6 is a class of high-speed electric multiple unit trains used on the Allegro service between Finland and Russia.
-
B.
SPR
The Strategic Petroleum Reserve (SPR) is the United States’ emergency stockpile of crude oil maintained to mitigate disruptions in petroleum supplies.
-
C.
SPR
SPR is the standard abbreviation for the Springfield Thunderbirds, a professional ice hockey team in the American Hockey League.
-
D.
SMND
SMND is the station code for the central Paris RER railway station Saint-Michel–Notre-Dame, a major hub near Notre-Dame Cathedral.
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E.
SPS
SPS is a high-energy circular particle accelerator at CERN that serves as a key injector for the Large Hadron Collider and supports a wide range of physics experiments.
- F. None of above. chosen
- G. Unsure - the case is ambiguous/there is not enough information to decide.
NED2
Entity disambiguation (via description)
gpt-5-mini-2025-08-07
Target entity: Sm proteins Target entity description: Sm proteins are a family of small, evolutionarily conserved RNA-binding proteins that form the core of small nuclear ribonucleoproteins (snRNPs) essential for pre-mRNA splicing in eukaryotic cells.
-
A.
Sm6
Sm6 is a class of high-speed electric multiple unit trains used on the Allegro service between Finland and Russia.
-
B.
SPR
The Strategic Petroleum Reserve (SPR) is the United States’ emergency stockpile of crude oil maintained to mitigate disruptions in petroleum supplies.
-
C.
SPR
SPR is the standard abbreviation for the Springfield Thunderbirds, a professional ice hockey team in the American Hockey League.
-
D.
SMND
SMND is the station code for the central Paris RER railway station Saint-Michel–Notre-Dame, a major hub near Notre-Dame Cathedral.
-
E.
SPS
SPS is a high-energy circular particle accelerator at CERN that serves as a key injector for the Large Hadron Collider and supports a wide range of physics experiments.
- F. None of above. chosen
Statements (49)
| Predicate | Object |
|---|---|
| instanceOf |
RNA-binding protein
ⓘ
eukaryotic protein complex component ⓘ protein family ⓘ |
| bindsMolecule |
RNA
ⓘ
small nuclear RNA ⓘ |
| bindsSequenceMotif |
AU-rich Sm site
ⓘ
Sm site ⓘ |
| formsComplexWith |
U1 snRNA
ⓘ
linked to:
RNA
U2 snRNA ⓘ U4 snRNA ⓘ U5 snRNA ⓘ |
| formsPartOf |
small nuclear ribonucleoproteins
ⓘ
snRNP core ⓘ |
| hasAlternativeName |
Sm core proteins
ⓘ
linked to:
Sm proteins
Sm-class proteins ⓘ |
| hasMember |
SmB
ⓘ
SmB' ⓘ SmD1 ⓘ SmD2 ⓘ SmD3 ⓘ SmE ⓘ SmF ⓘ SmG ⓘ |
| hasMolecularFunction |
RNA binding
ⓘ
snRNP assembly factor binding ⓘ |
| hasStructuralFeature |
Sm fold
ⓘ
beta-sheet rich domain ⓘ |
| interactsWith |
Gemin proteins
ⓘ
linked to:
Gemin6
SMN complex ⓘ |
| isAbsentFrom | U6 snRNP ⓘ |
| isAssociatedWithDisease | systemic lupus erythematosus ⓘ |
| isComponentOf |
U1 snRNP
ⓘ
U2 snRNP ⓘ U4 snRNP ⓘ U5 snRNP ⓘ |
| isEncodedBy | multiple nuclear genes ⓘ |
| isEssentialFor |
pre-mRNA splicing
ⓘ
spliceosome function ⓘ |
| isEvolutionarilyConserved | true ⓘ |
| isPostTranslationallyModifiedBy |
methylation
ⓘ
phosphorylation ⓘ |
| isTargetOf | anti-Sm autoantibodies ⓘ |
| localizesTo |
Cajal bodies
ⓘ
nuclear speckles ⓘ nucleus ⓘ |
| occursIn | eukaryotic cells ⓘ |
| participatesIn |
pre-mRNA processing
ⓘ
snRNP biogenesis ⓘ spliceosome assembly ⓘ |
How these facts were elicited
The pipeline generated the facts above by prompting gpt-5.1 with this entity's name + description and the instruction below.
Instruction
You are a knowledge base construction expert. Given a subject entity and a description of it, return factual statements that you know for the subject as a JSON list of dictionaries(triples), where keys must be "subject", "predicate" and "object". The number of facts may be very high, between 25 to 50 or more, for very popular subjects. For less popular subjects, the number of facts can be very low, like 5 or 10. # Requirements - If you don't know the subject at all, return an empty list. - If the subject is not a named entity, return an empty list. - Include at least one triple where predicate is "instanceOf". - Do not get too wordy. - Separate several objects into multiple triples with one object.
Input
Subject: Sm proteins Description of subject: Sm proteins are a family of small, evolutionarily conserved RNA-binding proteins that form the core of small nuclear ribonucleoproteins (snRNPs) essential for pre-mRNA splicing in eukaryotic cells.
Referenced by (5)
Full triples — surface form annotated when it differs from this entity's canonical label.