Gemin4
E561086
Gemin4 is a core component of the SMN (survival motor neuron) complex involved in the assembly and maturation of small nuclear ribonucleoproteins (snRNPs) essential for pre-mRNA splicing.
All labels observed (2)
How this entity was disambiguated
This entity first appeared as the object of triple T6004690 — resolving that mention is where its identity was fixed. The disambiguator weighed these candidate entities and picked the highlighted one (or “None”, minting a new entity). This is how homonymy is resolved: the same surface form can point to different entities.
NED1
Entity disambiguation (via context triple)
gpt-5-mini-2025-08-07
Target entity: Gemin4 Context triple: [Survival motor neuron protein, formsComplexWith, Gemin4]
-
A.
Cygnus spacecraft
The Cygnus spacecraft is an uncrewed commercial cargo vehicle developed by Northrop Grumman to deliver supplies and scientific equipment to the International Space Station.
-
B.
BE-4
The BE-4 is Blue Origin’s next-generation methane-fueled rocket engine designed to power modern heavy-lift launch vehicles such as United Launch Alliance’s Vulcan rocket.
-
C.
ISS ExPRESS Logistics Carrier 2
ISS ExPRESS Logistics Carrier 2 is an external payload platform on the International Space Station used to host and support various scientific instruments and experiments.
-
D.
STS-134
STS-134 was the penultimate mission of NASA’s Space Shuttle program, a 2011 flight of Endeavour to the International Space Station that delivered the Alpha Magnetic Spectrometer and other critical hardware.
-
E.
Artemis III
Artemis III is a planned NASA mission intended to return humans to the lunar surface, including the first woman and next man to land on the Moon, as part of the broader Artemis lunar exploration program.
- F. None of above. chosen
- G. Unsure - the case is ambiguous/there is not enough information to decide.
NED2
Entity disambiguation (via description)
gpt-5-mini-2025-08-07
Target entity: Gemin4 Target entity description: Gemin4 is a core component of the SMN (survival motor neuron) complex involved in the assembly and maturation of small nuclear ribonucleoproteins (snRNPs) essential for pre-mRNA splicing.
-
A.
Cygnus spacecraft
The Cygnus spacecraft is an uncrewed commercial cargo vehicle developed by Northrop Grumman to deliver supplies and scientific equipment to the International Space Station.
-
B.
BE-4
The BE-4 is Blue Origin’s next-generation methane-fueled rocket engine designed to power modern heavy-lift launch vehicles such as United Launch Alliance’s Vulcan rocket.
-
C.
ISS ExPRESS Logistics Carrier 2
ISS ExPRESS Logistics Carrier 2 is an external payload platform on the International Space Station used to host and support various scientific instruments and experiments.
-
D.
STS-134
STS-134 was the penultimate mission of NASA’s Space Shuttle program, a 2011 flight of Endeavour to the International Space Station that delivered the Alpha Magnetic Spectrometer and other critical hardware.
-
E.
Artemis III
Artemis III is a planned NASA mission intended to return humans to the lunar surface, including the first woman and next man to land on the Moon, as part of the broader Artemis lunar exploration program.
- F. None of above. chosen
Statements (40)
| Predicate | Object |
|---|---|
| instanceOf |
SMN complex component
ⓘ
protein ⓘ |
| alias |
GEMIN4
ⓘ
linked to:
Gemin4
gem-associated protein 4 ⓘ
linked to:
GEMIN4 gene
|
| associatedWithDiseaseMechanism | defective snRNP biogenesis ⓘ |
| associatedWithPathway |
RNA transport and processing pathways
ⓘ
spliceosome pathway ⓘ |
| associatedWithProcess |
RNA processing
ⓘ
mRNA splicing via spliceosome ⓘ spliceosomal snRNP biogenesis ⓘ |
| bindsTo |
Gemin2
ⓘ
Gemin3 ⓘ SMN protein ⓘ
linked to:
survival motor neuron protein
small nuclear RNAs ⓘ |
| biologicalRole |
maintenance of snRNP levels
ⓘ
regulation of spliceosome composition ⓘ |
| cellularComponent |
SMN–Gemin complex
ⓘ
linked to:
SMN complex
ribonucleoprotein complex ⓘ |
| conservedIn | vertebrates ⓘ |
| encodedBy | GEMIN4 gene ⓘ |
| essentialFor |
efficient pre-mRNA splicing
ⓘ
proper assembly of spliceosomal snRNPs ⓘ |
| inComplexWith |
Gemin5
ⓘ
Gemin6 ⓘ Gemin7 ⓘ Gemin8 ⓘ SMN1 protein ⓘ
linked to:
SMN1 gene
|
| locatedIn |
Gems (Gemini of Cajal bodies)
ⓘ
linked to:
gems (Gemini of Cajal bodies)
cytoplasm ⓘ nucleus ⓘ |
| molecularFunction |
RNA binding
ⓘ
protein binding ⓘ |
| organism | Homo sapiens ⓘ |
| participatesIn |
SMN complex assembly
ⓘ
pre-mRNA splicing ⓘ snRNP assembly ⓘ snRNP maturation ⓘ |
| partOf | SMN complex ⓘ |
| subcellularLocalization |
Cajal body-associated structures
ⓘ
nuclear bodies ⓘ |
How these facts were elicited
The pipeline generated the facts above by prompting gpt-5.1 with this entity's name + description and the instruction below.
Instruction
You are a knowledge base construction expert. Given a subject entity and a description of it, return factual statements that you know for the subject as a JSON list of dictionaries(triples), where keys must be "subject", "predicate" and "object". The number of facts may be very high, between 25 to 50 or more, for very popular subjects. For less popular subjects, the number of facts can be very low, like 5 or 10. # Requirements - If you don't know the subject at all, return an empty list. - If the subject is not a named entity, return an empty list. - Include at least one triple where predicate is "instanceOf". - Do not get too wordy. - Separate several objects into multiple triples with one object.
Input
Subject: Gemin4 Description of subject: Gemin4 is a core component of the SMN (survival motor neuron) complex involved in the assembly and maturation of small nuclear ribonucleoproteins (snRNPs) essential for pre-mRNA splicing.
Referenced by (8)
Full triples — surface form annotated when it differs from this entity's canonical label.