E3 ubiquitin ligase superfamily
GPTKB entity
Statements (23)
| Predicate | Object |
|---|---|
| gptkbp:instanceOf |
superfamily
|
| gptkbp:contains |
HECT-type E3 ligases
RBR-type E3 ligases RING-type E3 ligases |
| gptkbp:dysregulationAssociatedWith |
gptkb:cancer
neurodegenerative diseases autoimmune diseases |
| gptkbp:foundIn |
eukaryotes
|
| gptkbp:function |
catalyzes transfer of ubiquitin to substrate proteins
|
| gptkbp:hasMember |
gptkb:APC/C
gptkb:MDM2 gptkb:Parkin gptkb:c-Cbl SCF complex |
| https://www.w3.org/2000/01/rdf-schema#label |
E3 ubiquitin ligase superfamily
|
| gptkbp:involvedIn |
ubiquitin-proteasome system
|
| gptkbp:regulates |
signal transduction
DNA repair immune response cell cycle protein degradation |
| gptkbp:bfsParent |
gptkb:HECT_E3_ubiquitin_ligase_family
|
| gptkbp:bfsLayer |
8
|