|
gptkbp:instanceOf
|
gptkb:protein
|
|
gptkbp:cofactor
|
Mg2+
|
|
gptkbp:component
|
gptkb:DNA_gyrase
|
|
gptkbp:EC_number
|
5.99.1.3
|
|
gptkbp:encodedBy
|
gyrA gene
|
|
gptkbp:Entrez_Gene_ID
|
945006
|
|
gptkbp:formsComplexWith
|
gptkb:GyrB
|
|
gptkbp:foundIn
|
gptkb:Bacteria
|
|
gptkbp:fullName
|
DNA gyrase subunit A
|
|
gptkbp:function
|
gptkb:DNA_supercoiling
ATP-dependent DNA negative supercoiling
|
|
gptkbp:GOProcess
|
DNA topological change
|
|
gptkbp:hasActiveSite
|
tyrosine residue
|
|
gptkbp:hasAlphaHelixContent
|
high
|
|
gptkbp:hasBetaSheetContent
|
present
|
|
gptkbp:hasBiologicalActivity
|
DNA topoisomerase activity
|
|
gptkbp:hasComponent
|
gptkb:cytoplasm
|
|
gptkbp:hasGOFunction
|
DNA binding
ATPase activity
|
|
gptkbp:hasPfamDomain
|
PF00521
|
|
gptkbp:hasRefSeqID
|
NP_414726.1
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
GyrA
|
|
gptkbp:inhibitedBy
|
gptkb:nalidixic_acid
gptkb:levofloxacin
ciprofloxacin
|
|
gptkbp:InterPro
|
IPR006171
|
|
gptkbp:involvedIn
|
DNA replication
chromosome segregation
|
|
gptkbp:KEGGID
|
eco:b2231
|
|
gptkbp:molecularWeight
|
~97 kDa
|
|
gptkbp:mutationAssociatedWith
|
antibiotic resistance
Asp87
Ser83
|
|
gptkbp:orthologIn
|
gptkb:Salmonella_enterica
gptkb:Pseudomonas_aeruginosa
gptkb:Neisseria_gonorrhoeae
gptkb:Acinetobacter_baumannii
gptkb:Klebsiella_pneumoniae
|
|
gptkbp:PDB
|
1AB4
4Z2C
|
|
gptkbp:presentIn
|
gptkb:Mycobacterium_tuberculosis
gptkb:Staphylococcus_aureus
gptkb:Bacteria
|
|
gptkbp:requires
|
bacterial viability
|
|
gptkbp:structure
|
homodimer
|
|
gptkbp:subcellularLocation
|
gptkb:cytoplasm
|
|
gptkbp:target
|
quinolone antibiotics
|
|
gptkbp:UniProtID
|
P0AES6
|
|
gptkbp:bfsParent
|
gptkb:DNA_gyrase
|
|
gptkbp:bfsLayer
|
6
|