|
gptkbp:instanceOf
|
gptkb:enzyme
|
|
gptkbp:activity
|
bifunctional
monofunctional
|
|
gptkbp:catalyzes
|
removal of damaged bases
|
|
gptkbp:cofactor
|
none required
|
|
gptkbp:discoveredBy
|
gptkb:Tomas_Lindahl
|
|
gptkbp:EC_number
|
3.2.2.-
|
|
gptkbp:firstDescribed
|
1970s
|
|
gptkbp:foundIn
|
gptkb:Bacteria
archaea
eukaryotes
|
|
gptkbp:function
|
base excision repair
|
|
gptkbp:GO_term
|
gptkb:GO:0019104
|
|
gptkbp:hasMember
|
gptkb:TDG
gptkb:MPG
gptkb:MUTYH
gptkb:NEIL1
gptkb:NEIL2
gptkb:NEIL3
gptkb:OGG1
gptkb:uracil-DNA_glycosylase
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
DNA glycosylases
|
|
gptkbp:involvedIn
|
DNA repair pathway
|
|
gptkbp:mechanismOfAction
|
cleaves N-glycosidic bond
|
|
gptkbp:mutationAssociatedWith
|
increased cancer risk
genomic instability
|
|
gptkbp:regulates
|
histone modification
protein-protein interactions
|
|
gptkbp:removes
|
gptkb:8-oxoguanine
gptkb:hypoxanthine
uracil
alkylated bases
deaminated bases
oxidized bases
thymine glycol
|
|
gptkbp:role
|
genome stability
|
|
gptkbp:significance
|
cancer prevention
aging
neurodegenerative diseases
|
|
gptkbp:structure
|
contains catalytic domain
contains DNA-binding domain
|
|
gptkbp:substrate
|
gptkb:gene
|
|
gptkbp:bfsParent
|
gptkb:BER
|
|
gptkbp:bfsLayer
|
6
|