Statements (28)
| Predicate | Object |
|---|---|
| gptkbp:instanceOf |
gptkb:enzyme
|
| gptkbp:alternativeName |
gptkb:UDG
uracil N-glycosylase uracil excisionase |
| gptkbp:catalyzes |
hydrolysis of the N-glycosidic bond between uracil and deoxyribose
|
| gptkbp:discoveredBy |
1974
|
| gptkbp:EC_number |
3.2.2.27
|
| gptkbp:encodedBy |
UNG gene
|
| gptkbp:foundIn |
gptkb:Bacteria
archaea eukaryotes |
| gptkbp:function |
removes uracil from DNA
|
| gptkbp:gene |
gptkb:UNG
|
| https://www.w3.org/2000/01/rdf-schema#label |
uracil-DNA glycosylase
|
| gptkbp:inhibitedBy |
uracil-DNA glycosylase inhibitor protein (Ugi)
|
| gptkbp:involves |
base excision repair
|
| gptkbp:molecularWeight |
~25 kDa
|
| gptkbp:PDB |
1AKZ
|
| gptkbp:product |
apyrimidinic site
|
| gptkbp:removes |
uracil from DNA caused by cytosine deamination
uracil misincorporated during DNA replication |
| gptkbp:requires |
genome integrity
|
| gptkbp:structure |
monomeric protein
|
| gptkbp:substrate |
uracil-containing DNA
|
| gptkbp:used_in |
molecular biology techniques
PCR contamination control |
| gptkbp:bfsParent |
gptkb:DNA_glycosylases
|
| gptkbp:bfsLayer |
7
|