DB00752

GPTKB entity

Statements (58)
Predicate Object
gptkbp:instanceOf gptkb:drug
gptkbp:approvedBy gptkb:FDA
gptkb:EMA
gptkbp:ATCCode A10BA02
gptkbp:bioavailability 50-60%
gptkbp:brand gptkb:Diabex
gptkb:Diaformin
gptkb:Metforal
gptkb:Riomet
gptkb:Siofor
gptkb:Fortamet
gptkb:Glucophage
gptkb:Glumetza
gptkbp:CASNumber 657-24-9
gptkbp:contraindication metabolic acidosis
hypersensitivity
renal impairment
hepatic impairment
gptkbp:discoveredBy gptkb:Jean_Sterne
gptkbp:discoveredIn 1957
gptkbp:drugClass biguanide
gptkbp:eliminationHalfLife 4-8.7 hours
gptkbp:excretion renal
gptkbp:hasInChIKey gptkb:XZWYZXLIPXDOLR-UHFFFAOYSA-N
gptkbp:hasMolecularFormula C4H11N5
gptkbp:hasSMILES CN(C)C(=N)N=C(N)N
gptkbp:hasTabletStrengths 500 mg
1000 mg
850 mg
gptkbp:hasUNII 9100L32L2N
https://www.w3.org/2000/01/rdf-schema#label DB00752
gptkbp:isApprovedDrug true
gptkbp:isGeneric true
gptkbp:mechanismOfAction decreases hepatic glucose production
increases insulin sensitivity
decreases intestinal absorption of glucose
gptkbp:metabolism not metabolized
gptkbp:molecularWeight 129.164
gptkbp:name gptkb:Metformin
gptkbp:pregnancyCategory B (US)
gptkbp:proteinBinding negligible
gptkbp:PubChem_CID gptkb:DB00752
gptkb:CHEMBL1431
gptkb:D01841
4091
gptkbp:routeOfAdministration oral
gptkbp:sideEffect nausea
diarrhea
gastrointestinal upset
lactic acidosis
gptkbp:synonym gptkb:Glucophage
gptkb:Metformina
gptkb:Metformine
gptkb:Metforminum
gptkbp:usedFor gptkb:type_2_diabetes_mellitus
gptkbp:bfsParent gptkb:Tranylcypromine
gptkb:tranylcypromine
gptkbp:bfsLayer 7