DB00318

GPTKB entity

Statements (57)
Predicate Object
gptkbp:instanceOf gptkb:drug
gptkbp:approvalYear 1994
gptkbp:ATCCode A10BA02
gptkbp:bioavailability 50-60%
gptkbp:brand gptkb:Riomet
gptkb:Fortamet
gptkb:Glucophage
gptkb:Glumetza
gptkbp:CASNumber 657-24-9
gptkbp:category antidiabetic agent
biguanide
gptkbp:contraindication metabolic acidosis
renal impairment
gptkbp:discoveredBy gptkb:Jean_Sterne
gptkbp:eliminationHalfLife 4-8.7 hours
gptkbp:excretion renal
gptkbp:firstMarketedYear 1957
gptkbp:form 500 mg
C4H11N5
1000 mg
850 mg
gptkbp:hasInChIKey gptkb:XZWYZXLIPXDOLR-UHFFFAOYSA-N
https://www.w3.org/2000/01/rdf-schema#label DB00318
gptkbp:indication gptkb:type_2_diabetes_mellitus
gptkbp:interactsWith gptkb:beer
cimetidine
furosemide
gptkbp:isOnWHOList true
gptkbp:KEGGID gptkb:D01841
gptkbp:legalStatus prescription only
gptkbp:marketedAs gptkb:France
gptkbp:maximumDosage 2550 mg/day
gptkbp:mechanismOfAction decreases hepatic glucose production
increases insulin sensitivity
gptkbp:metabolism not metabolized
gptkbp:molecularWeight 129.164
gptkbp:name gptkb:Metformin
gptkbp:origin synthetic
gptkbp:pharmacodynamics lowers blood glucose without causing hypoglycemia
gptkbp:pregnancyCategory B (US)
gptkbp:proteinBinding negligible
gptkbp:PubChem_CID gptkb:CHEMBL1431
gptkb:DB00318
4091
3949
gptkbp:routeOfAdministration oral
gptkbp:sideEffect gastrointestinal upset
lactic acidosis
gptkbp:smiles CN(C)C(=N)N=C(N)N
gptkbp:synonym 1,1-dimethylbiguanide
dimethylbiguanide
gptkbp:target gptkb:AMP-activated_protein_kinase
gptkbp:toxicity lactic acidosis risk
gptkbp:UNII 9100L32L2N
gptkbp:bfsParent gptkb:Codeine
gptkb:codeine
gptkbp:bfsLayer 6