|
gptkbp:instanceOf
|
immune response
cell surface receptor
lymphocyte
|
|
gptkbp:activatedBy
|
dendritic cells
antigen-presenting cells
|
|
gptkbp:alsoKnownAs
|
gptkb:CTL
gptkb:CD8+_T_cell
|
|
gptkbp:developedBy
|
thymocyte
|
|
gptkbp:distinctiveFeature
|
gptkb:effector_T_cell
memory T cell
|
|
gptkbp:expressedIn
|
gptkb:CD8_glycoprotein
|
|
gptkbp:firstDescribed
|
gptkb:Peter_Doherty
gptkb:Rolf_Zinkernagel
|
|
gptkbp:foundIn
|
blood
lymphoid tissues
|
|
gptkbp:function
|
kills damaged cells
kills virus-infected cells
kills tumor cells
|
|
gptkbp:hasRole
|
immunotherapy
autoimmune diseases
transplant rejection
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
Cytotoxic T Lymphocyte
|
|
gptkbp:importantFor
|
cancer immunosurveillance
viral clearance
elimination of intracellular pathogens
|
|
gptkbp:inducedBy
|
apoptosis in target cells
|
|
gptkbp:involvedIn
|
cell-mediated immunity
|
|
gptkbp:lifespan
|
weeks to years
|
|
gptkbp:marking
|
gptkb:CD8
gptkb:T_cell_receptor_(TCR)
|
|
gptkbp:maturation
|
gptkb:thymus
|
|
gptkbp:measures
|
gptkb:ELISPOT_assay
flow cytometry
cytotoxicity assay
|
|
gptkbp:partOf
|
gptkb:adaptive_immune_system
|
|
gptkbp:predecessor
|
naive CD8+ T cell
|
|
gptkbp:proliferatesInResponseTo
|
gptkb:interleukin-2
|
|
gptkbp:recognizedBy
|
antigen presented by MHC class I
|
|
gptkbp:secretes
|
gptkb:granzymes
gptkb:perforin
granulysin
|
|
gptkbp:target
|
gptkb:HIV
immunosuppressive drugs
|
|
gptkbp:bfsParent
|
gptkb:CTL
|
|
gptkbp:bfsLayer
|
6
|