|
gptkbp:instanceOf
|
gptkb:gene
|
|
gptkbp:alias
|
gptkb:CYP7
gptkb:cholesterol_7-alpha-monooxygenase
|
|
gptkbp:associatedWith
|
gptkb:familial_hypercholesterolemia
cholestasis
|
|
gptkbp:biologicalProcess
|
oxidoreductase activity
bile acid metabolic process
cholesterol catabolic process
|
|
gptkbp:encodes
|
CYP7A1 protein
|
|
gptkbp:Entrez_Gene_ID
|
13122 (mouse)
1581 (human)
|
|
gptkbp:enzymeCommissionNumber
|
1.14.14.23
|
|
gptkbp:expressedIn
|
liver
|
|
gptkbp:fullName
|
gptkb:cholesterol_7_alpha-hydroxylase
|
|
gptkbp:function
|
catalyzes the rate-limiting step in bile acid synthesis
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
Cyp7a1
|
|
gptkbp:locatedOnChromosome
|
4 (mouse)
8 (human)
|
|
gptkbp:location
|
gptkb:endoplasmic_reticulum
|
|
gptkbp:mutationAssociatedWith
|
can cause bile acid deficiency
|
|
gptkbp:organism
|
gptkb:Mus_musculus
gptkb:Homo_sapiens
|
|
gptkbp:orthologIn
|
CYP7A1 (human)
Cyp7a1 (mouse)
|
|
gptkbp:pathway
|
bile acid biosynthesis
|
|
gptkbp:proteinFamily
|
gptkb:cytochrome_P450
|
|
gptkbp:regulates
|
inhibited by bile acids
regulated by FXR (farnesoid X receptor)
regulated by LXR (liver X receptor)
|
|
gptkbp:UniProtID
|
P22680 (human)
Q64435 (mouse)
|
|
gptkbp:bfsParent
|
gptkb:CYP7A1
|
|
gptkbp:bfsLayer
|
6
|