cholesterol 7-alpha-monooxygenase
GPTKB entity
Statements (23)
| Predicate | Object |
|---|---|
| gptkbp:instanceOf |
gptkb:enzyme
|
| gptkbp:alsoKnownAs |
gptkb:CYP7A1
|
| gptkbp:catalyzes |
hydroxylation of cholesterol at the 7-alpha position
|
| gptkbp:cofactor |
hemoglobin
NADPH |
| gptkbp:deficiencyCauses |
gptkb:familial_hypercholesterolemia
|
| gptkbp:EC_number |
1.14.14.23
|
| gptkbp:enzymeClassification |
oxidoreductase
|
| gptkbp:foundIn |
liver
|
| gptkbp:gene |
gptkb:CYP7A1
|
| https://www.w3.org/2000/01/rdf-schema#label |
cholesterol 7-alpha-monooxygenase
|
| gptkbp:human_gene_location |
chromosome 8q11-q12
|
| gptkbp:involves |
bile acid biosynthesis
|
| gptkbp:locatedIn |
gptkb:endoplasmic_reticulum
|
| gptkbp:member |
gptkb:protein
|
| gptkbp:OMIM |
118425
|
| gptkbp:product |
7-alpha-hydroxycholesterol
|
| gptkbp:regulates |
feedback inhibited by bile acids
|
| gptkbp:requires |
cholesterol catabolism
|
| gptkbp:substrate |
cholesterol
|
| gptkbp:UniProtID |
gptkb:P22680
|
| gptkbp:bfsParent |
gptkb:CYP7A1
|
| gptkbp:bfsLayer |
6
|