Chronic Lymphocytic Leukemia

URI: https://gptkb.org/entity/Chronic_Lymphocytic_Leukemia
GPTKB entity
Statements (64)
Predicate Object
gptkbp:instanceOf gptkb:disease
leukemia
gptkbp:abbreviation gptkb:CLL
gptkbp:affects gptkb:B_lymphocytes
immune system
gptkbp:associatedWith gptkb:trisomy_12
chromosome 11q deletion
chromosome 13q deletion
chromosome 17p deletion
gptkbp:complication gptkb:autoimmune_hemolytic_anemia
infections
hypogammaglobulinemia
secondary cancers
Richter's transformation
gptkbp:firstDescribed 1845
Virchow
gptkbp:hasDiagnosticMethod bone marrow biopsy
complete blood count
flow cytometry
gptkbp:hasOrphanetID 67047
https://www.w3.org/2000/01/rdf-schema#label Chronic Lymphocytic Leukemia
gptkbp:ICD-10_code C91.1
gptkbp:isMostCommonIn older adults
gptkbp:isMostCommonLeukemiaIn Western countries
gptkbp:medianAge 70 years
gptkbp:MeSH_ID D015451
gptkbp:notable_drug gptkb:cyclophosphamide
gptkb:rituximab
gptkb:ofatumumab
gptkb:bendamustine
gptkb:obinutuzumab
gptkb:chlorambucil
gptkb:fludarabine
gptkb:ibrutinib
gptkb:venetoclax
alemtuzumab
gptkbp:OMIM 151400
gptkbp:prevalence most common adult leukemia in Western countries
gptkbp:prognosis variable
gptkbp:rareIn gptkb:Asian_populations
children
gptkbp:riskFactor family history
male sex
advanced age
Caucasian ethnicity
gptkbp:stageName Binet system
Rai system
gptkbp:subspecies chronic leukemia
lymphocytic leukemia
gptkbp:symptom gptkb:anemia
fatigue
weight loss
night sweats
frequent infections
enlarged lymph nodes
gptkbp:synonym gptkb:CLL
gptkb:chronic_lymphoid_leukemia
gptkbp:treatment astronomer
chemotherapy
immunotherapy
targeted therapy
stem cell transplant
gptkbp:bfsParent gptkb:CLL
gptkbp:bfsLayer 7