Chitinase-3-like protein 1

URI: https://gptkb.org/entity/Chitinase-3-like_protein_1
GPTKB entity
Statements (50)
Predicate Object
gptkbp:instanceOf gptkb:protein
gptkbp:alsoKnownAs gptkb:CHI3L1
YKL-40
gptkbp:associatedWith gptkb:cancer
asthma
osteoarthritis
rheumatoid arthritis
liver fibrosis
gptkbp:discoveredIn 1992
gptkbp:encodedBy gptkb:CHI3L1_gene
gptkbp:Entrez_Gene_ID 1116
gptkbp:enzyme lacks chitinase activity
gptkbp:expressedIn macrophages
neutrophils
chondrocytes
synovial cells
gptkbp:foundIn gptkb:Homo_sapiens
gptkbp:function cell proliferation
angiogenesis
tissue remodeling
glycoprotein involved in inflammation
gptkbp:hasBiomarker inflammation
tissue remodeling
gptkbp:hasNo chitinase enzymatic activity
gptkbp:homologInRat gp38
https://www.w3.org/2000/01/rdf-schema#label Chitinase-3-like protein 1
gptkbp:interactsWith gptkb:chitin
gptkb:heparin
collagen
gptkbp:length 383 amino acids
gptkbp:locatedOnChromosome 1q32.1
gptkbp:medicalUse serum biomarker
gptkbp:memberOf glycoside hydrolase family 18
gptkbp:molecularWeight 40 kDa
gptkbp:OMIM 600417
gptkbp:orthologInMouse BRP-39
gptkbp:PDB 1NWR
gptkbp:postTranslationalModification gptkb:N-glycosylation
gptkbp:secretes neutrophils
chondrocytes
synovial cells
activated macrophages
gptkbp:structure glycosyl hydrolase family 18
gptkbp:subcellularLocation secreted
gptkbp:UniProtID P36222
gptkbp:usedAs prognostic marker in cancer
marker for joint diseases
gptkbp:bfsParent gptkb:YK40
gptkb:KL-40
gptkbp:bfsLayer 7