SN-38

GPTKB entity

Statements (31)
Predicate Object
gptkbp:instanceOf gptkb:chemical_compound
gptkbp:active_metabolite_of gptkb:irinotecan
gptkbp:CASNumber 86639-52-3
gptkbp:category alkaloid
antineoplastic agent
lactone
gptkbp:derivedFrom gptkb:irinotecan
gptkbp:drugClass topoisomerase inhibitor
gptkbp:hasInChIKey QBPZKZZCQLOAIF-VCHYOVAHSA-N
gptkbp:hasMolecularFormula C22H20N2O5
gptkbp:hasSMILES CC[C@H]1C2=C(C=CC(=C2)O)C3=C4C(=O)N(C)C(=O)C4=CC5=C3C1=CC=C5
https://www.w3.org/2000/01/rdf-schema#label SN-38
gptkbp:IUPACName (20S)-7-ethyl-10-hydroxycamptothecin
gptkbp:mechanismOfAction inhibits topoisomerase I
gptkbp:metabolism gptkb:UGT1A1
gptkbp:molecularWeight 392.41 g/mol
gptkbp:PubChem_CID gptkb:CHEMBL190836
104842
CHEBI:9027
gptkbp:relatedTo gptkb:camptothecin
gptkbp:routeOfAdministration intravenous (as irinotecan prodrug)
gptkbp:solubility poorly soluble in water
gptkbp:toxicity diarrhea
myelosuppression
gptkbp:UNII 2Y1W8T8A7X
gptkbp:used_in cancer chemotherapy
gptkbp:bfsParent gptkb:irinotecan
gptkb:PEN-866
gptkb:Camptothecin
gptkb:Trodelvy
gptkbp:bfsLayer 7