Statements (127)
| Predicate | Object |
|---|---|
| gptkbp:instance_of |
gptkb:DNA
gptkb:Biology |
| gptkbp:affects |
anticonvulsant drug levels
antidepressant drug levels antidepressant levels antidiabetic drug levels antihypertensive drug levels antimalarial drug levels antiviral drug levels immunosuppressant drug levels immunosuppressant levels neurological drug levels |
| gptkbp:associated_with |
liver disease
adverse drug reactions drug-drug interactions |
| gptkbp:character_traits |
gptkb:CYP3_A4*22
genetic variations CYP3 A4*1 B |
| gptkbp:code |
cytochrome P450 3 A4 protein
|
| gptkbp:contributes_to |
drug clearance
|
| gptkbp:function |
metabolism of drugs
|
| gptkbp:has_role |
therapeutic drug monitoring
cholesterol metabolism steroid metabolism xenobiotic metabolism vitamin D metabolism fatty acid metabolism bile acid metabolism retinoic acid metabolism endogenous compound metabolism environmental chemical metabolism |
| gptkbp:has_variants |
gptkb:CYP3_A4*1_A
gptkb:CYP3_A4*22 gptkb:CYP3_A4*4 gptkb:CYP3_A4*5 gptkb:CYP3_A4*11 gptkb:CYP3_A4*12 gptkb:CYP3_A4*13 gptkb:CYP3_A4*10 gptkb:CYP3_A4*6 gptkb:CYP3_A4*8 gptkb:CYP3_A4*9 CYP3 A4*1 C CYP3 A4*14 CYP3 A4*15 CYP3 A4*16 CYP3 A4*17 CYP3 A4*18 CYP3 A4*19 CYP3 A4*20 CYP3 A4*21 CYP3 A4*23 CYP3 A4*24 CYP3 A4*25 CYP3 A4*26 CYP3 A4*27 CYP3 A4*28 CYP3 A4*29 CYP3 A4*3 CYP3 A4*30 CYP3 A4*7 |
| https://www.w3.org/2000/01/rdf-schema#label |
CYP3 A4
|
| gptkbp:induced_by |
gptkb:St._John's_Wort
gptkb:rifampicin |
| gptkbp:inducer_of |
certain drugs
|
| gptkbp:influences |
drug efficacy
pharmacokinetics adverse drug reactions anticoagulant therapy pain management drugs bioavailability of drugs anesthetic drug levels anticoagulant drug levels antifungal drug levels antineoplastic drug levels cancer drug efficacy immunotherapy drug levels opioid metabolism thyroid medication levels |
| gptkbp:inhibitor_of |
various drugs
|
| gptkbp:initiated_by |
gptkb:ketoconazole
gptkb:ritonavir |
| gptkbp:interacts_with |
herbal supplements
statins antiparasitic drugs anticonvulsants HIV medications antiviral agents antiretroviral drugs antineoplastic agents antihypertensive agents |
| gptkbp:involved_in |
cholesterol metabolism
steroid metabolism xenobiotic metabolism drug metabolism hormone synthesis antibiotic metabolism antihistamine metabolism antipsychotic drug metabolism antipsychotic metabolism cardiovascular drug metabolism corticosteroid metabolism gastrointestinal drug metabolism hormonal drug metabolism psychoactive drug metabolism |
| gptkbp:is_essential_for |
pharmacogenomics
|
| gptkbp:is_expressed_in |
gptkb:Brain
liver intestine |
| gptkbp:is_found_in |
mice
rats primates |
| gptkbp:is_regulated_by |
gptkb:constitutive_androstane_receptor
gptkb:pregnane_X_receptor various factors |
| gptkbp:located_in |
liver
human chromosome 7 |
| gptkbp:metabolism |
gptkb:simvastatin
gptkb:erythromycin gptkb:carbamazepine testosterone midazolam |
| gptkbp:promoter |
CYP3 A4 gene
|
| gptkbp:role |
drug interactions
|
| gptkbp:substrate_of |
many medications
|
| gptkbp:bfsParent |
gptkb:Biology
|
| gptkbp:bfsLayer |
3
|