|
gptkbp:instanceOf
|
gptkb:gene
|
|
gptkbp:alias
|
CYP2J2 enzyme
cytochrome P450, family 2, subfamily J, polypeptide 2
|
|
gptkbp:associatedWith
|
gptkb:cardiovascular_disease
hypertension
drug metabolism variability
|
|
gptkbp:discoveredBy
|
Nelson et al.
|
|
gptkbp:discoveredIn
|
1996
|
|
gptkbp:encodes
|
cytochrome P450 2J2
|
|
gptkbp:Entrez_Gene_ID
|
1573
|
|
gptkbp:enzymeCommissionNumber
|
gptkb:EC_1.14.14.1
|
|
gptkbp:expressedIn
|
gptkb:cancer
gptkb:kidney
brain
heart
liver
intestine
|
|
gptkbp:foundIn
|
gptkb:Homo_sapiens
|
|
gptkbp:function
|
monooxygenase activity
drug metabolism
synthesis of cholesterol, steroids, and other lipids
|
|
gptkbp:gene
|
gptkb:CYP2J2
|
|
gptkbp:geneType
|
protein coding
|
|
gptkbp:hasPolymorphism
|
CYP2J2*7
|
|
gptkbp:hasPseudogene
|
CYP2J2P1
|
|
gptkbp:hasTranscriptVariant
|
CYP2J2-201
CYP2J2-202
|
|
gptkbp:HGNC_ID
|
2592
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
CYP2J2
|
|
gptkbp:involvedIn
|
xenobiotic metabolism
fatty acid metabolism
epoxygenase pathway
|
|
gptkbp:length
|
502 amino acids
|
|
gptkbp:locatedOnChromosome
|
chromosome 1
1p31.3
|
|
gptkbp:memberOf
|
gptkb:cytochrome_P450_superfamily
|
|
gptkbp:molecularWeight
|
57 kDa
|
|
gptkbp:OMIM
|
601012
|
|
gptkbp:orthologInMouse
|
Cyp2j3
Cyp2j5
|
|
gptkbp:product
|
epoxyeicosatrienoic acids (EETs)
|
|
gptkbp:proteinFamily
|
gptkb:CYP2_family
|
|
gptkbp:regulates
|
inflammation
cardiac function
vascular tone
|
|
gptkbp:substrate
|
gptkb:arachidonic_acid
|
|
gptkbp:UniProtID
|
P51589
|
|
gptkbp:bfsParent
|
gptkb:CYP2_family
gptkb:CYP_family
|
|
gptkbp:bfsLayer
|
5
|