|
gptkbp:instanceOf
|
gptkb:drug
gptkb:anticoagulant
protease-activated receptor-1 antagonist
|
|
gptkbp:approvalYear
|
2014
|
|
gptkbp:approvedBy
|
gptkb:FDA
|
|
gptkbp:ATCCode
|
B01AX15
|
|
gptkbp:brand
|
Zontivity
|
|
gptkbp:CASNumber
|
618385-01-6
|
|
gptkbp:chemicalClass
|
trifluoromethylphenylpiperazine derivative
|
|
gptkbp:contraindication
|
active pathological bleeding
history of intracranial hemorrhage
history of stroke
history of transient ischemic attack
|
|
gptkbp:developer
|
gptkb:Merck_&_Co.
|
|
gptkbp:eliminationHalfLife
|
8 days
|
|
gptkbp:hasMolecularFormula
|
C29H33F2N3O4
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
Vorapaxar
|
|
gptkbp:KEGGID
|
D09913
|
|
gptkbp:legalStatus
|
prescription only
|
|
gptkbp:mechanismOfAction
|
inhibits PAR-1 receptor
|
|
gptkbp:metabolism
|
gptkb:CYP3A4
gptkb:CYP2J2
|
|
gptkbp:pregnancyCategory
|
N (Not classified)
|
|
gptkbp:proteinBinding
|
99%
|
|
gptkbp:PubChem_CID
|
gptkb:CHEMBL2103837
11571236
DB09093
|
|
gptkbp:routeOfAdministration
|
oral
|
|
gptkbp:sideEffect
|
gptkb:anemia
bleeding
|
|
gptkbp:synonym
|
SCH 530348
|
|
gptkbp:UNII
|
3Z54X8460I
|
|
gptkbp:usedFor
|
prevention of thrombotic cardiovascular events
secondary prevention of peripheral arterial disease
secondary prevention of myocardial infarction
|
|
gptkbp:bfsParent
|
gptkb:Servier_Pharmaceuticals
|
|
gptkbp:bfsLayer
|
7
|