|
gptkbp:instanceOf
|
gptkb:protein
|
|
gptkbp:alias
|
gptkb:CCCTC-binding_factor
11-zinc finger protein
transcriptional repressor CTCF
|
|
gptkbp:binds
|
gptkb:gene
CCCTC DNA motif
|
|
gptkbp:discoveredBy
|
gptkb:Gary_Felsenfeld
|
|
gptkbp:Entrez_Gene_ID
|
gptkb:ENSG00000102974
10664
|
|
gptkbp:expressedIn
|
many tissues
|
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gptkbp:fullName
|
gptkb:CCCTC-binding_factor
|
|
gptkbp:function
|
regulation of gene expression
transcriptional regulator
chromatin insulator
regulation of chromatin architecture
|
|
gptkbp:gene
|
gptkb:CTCF_gene
|
|
gptkbp:HGNC_ID
|
gptkb:HGNC:13723
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
CTCF
|
|
gptkbp:interactsWith
|
gptkb:YY1
gptkb:cohesin_complex
chromatin remodeling factors
|
|
gptkbp:involvedIn
|
gptkb:X-chromosome_inactivation
genomic imprinting
chromatin looping
regulation of TADs (topologically associating domains)
enhancer blocking
|
|
gptkbp:locatedOnChromosome
|
16q22.1
|
|
gptkbp:molecularWeight
|
82 kDa
|
|
gptkbp:mutationAssociatedWith
|
intellectual disability
neurodevelopmental disorders
growth retardation
|
|
gptkbp:numberOfZincFingers
|
11
|
|
gptkbp:OMIM
|
604167
|
|
gptkbp:organism
|
gptkb:Homo_sapiens
|
|
gptkbp:orthologIn
|
gptkb:mouse
gptkb:zebrafish
gptkb:Drosophila_melanogaster
|
|
gptkbp:PDB
|
5YEL
|
|
gptkbp:postTranslationalModification
|
phosphorylation
sumoylation
poly(ADP-ribosyl)ation
|
|
gptkbp:regulates
|
gptkb:MYC_gene
gptkb:H19/IGF2_locus
gptkb:beta-globin_locus
multiple imprinted genes
|
|
gptkbp:requires
|
embryonic development
|
|
gptkbp:structure
|
contains 11 C2H2-type zinc fingers
|
|
gptkbp:UniProtID
|
gptkb:P49711
|
|
gptkbp:bfsParent
|
gptkb:CTCFC
|
|
gptkbp:bfsLayer
|
7
|