|
gptkbp:instanceOf
|
gptkb:protein
gptkb:gene
|
|
gptkbp:alsoKnownAs
|
Necl-5
Poliovirus receptor
|
|
gptkbp:alternativeSplicing
|
yes
|
|
gptkbp:cytoplasmicDomain
|
present
|
|
gptkbp:discoveredBy
|
Mendelsohn et al.
|
|
gptkbp:discoveredIn
|
1989
|
|
gptkbp:encodedBy
|
PVR gene
|
|
gptkbp:Entrez_Gene_ID
|
5817
ENSG00000073008
|
|
gptkbp:expressedIn
|
endothelial cells
immune cells
epithelial cells
|
|
gptkbp:extracellularDomain
|
present
|
|
gptkbp:function
|
cell surface receptor
receptor for poliovirus
|
|
gptkbp:HGNC_ID
|
HGNC:9705
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
CD155 (PVR)
|
|
gptkbp:interactsWith
|
gptkb:TIGIT
CD96
CD226 (DNAM-1)
|
|
gptkbp:length
|
417 amino acids
|
|
gptkbp:locatedOnChromosome
|
gptkb:chromosome_19
19q13.31
|
|
gptkbp:location
|
gptkb:plasma_membrane
|
|
gptkbp:molecularWeight
|
44 kDa
|
|
gptkbp:OMIM
|
173445
|
|
gptkbp:orthologInMouse
|
Cd155
|
|
gptkbp:overexpressedIn
|
various cancers
|
|
gptkbp:postTranslationalModification
|
glycosylation
|
|
gptkbp:relatedTo
|
T cell activation
viral pathogenesis
tumor progression
immune checkpoint pathways
natural killer cell function
cellular adhesion
|
|
gptkbp:role
|
cell proliferation
cell migration
metastasis
oncogenesis
immune response modulation
viral entry
tumor immune evasion
|
|
gptkbp:structure
|
gptkb:immunoglobulin_superfamily
|
|
gptkbp:target
|
immunotherapy research
|
|
gptkbp:transmembraneDomains
|
present
|
|
gptkbp:UniProtID
|
P15151
|
|
gptkbp:bfsParent
|
gptkb:Poliovirus
|
|
gptkbp:bfsLayer
|
6
|