|
gptkbp:instanceOf
|
gptkb:protein
|
|
gptkbp:alternativeName
|
C1 inhibitor
SERPING1 protein
|
|
gptkbp:associatedWith
|
gptkb:hereditary_hemorrhagic_telangiectasia
|
|
gptkbp:deficiencyCauses
|
gptkb:acquired_angioedema
gptkb:hereditary_hemorrhagic_telangiectasia
|
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gptkbp:encodedBy
|
gptkb:SERPING1_gene
|
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gptkbp:fullName
|
gptkb:C1_esterase_inhibitor
|
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gptkbp:function
|
inhibits complement system
inhibits coagulation system
inhibits contact system
inhibits fibrinolytic system
|
|
gptkbp:gene
|
SERPING1
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
C1INH
|
|
gptkbp:inhibitedBy
|
gptkb:MASP-1
gptkb:MASP-2
gptkb:C1r
gptkb:C1s
gptkb:kallikrein
gptkb:factor_XIIa
gptkb:factor_XIa
plasmin
|
|
gptkbp:locatedOnChromosome
|
gptkb:chromosome_11q12-q13.1
|
|
gptkbp:location
|
blood plasma
|
|
gptkbp:medicalUse
|
replacement therapy for hereditary angioedema
|
|
gptkbp:molecularWeight
|
~105 kDa
|
|
gptkbp:OMIM
|
606860
|
|
gptkbp:producedBy
|
liver
endothelial cells
monocytes
|
|
gptkbp:proteinFamily
|
serpin
|
|
gptkbp:regulates
|
inflammatory response
complement activation
vascular permeability
|
|
gptkbp:structure
|
gptkb:protein
|
|
gptkbp:UniProtID
|
P05155
|
|
gptkbp:bfsParent
|
gptkb:C1_esterase_inhibitor
gptkb:C1-inhibitor
|
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gptkbp:bfsLayer
|
8
|