|
gptkbp:instanceOf
|
gptkb:protein
gptkb:serine_protease
|
|
gptkbp:administeredBy
|
intravenous injection
|
|
gptkbp:alternativeName
|
gptkb:C1INH
gptkb:C1-inhibitor
|
|
gptkbp:approvedDrugName
|
gptkb:Cinryze
gptkb:Haegarda
gptkb:Ruconest
gptkb:Berinert
|
|
gptkbp:deficiencyCauses
|
gptkb:hereditary_hemorrhagic_telangiectasia
|
|
gptkbp:deficiencyType
|
gptkb:Type_II_hereditary_angioedema
gptkb:Type_I_hereditary_angioedema
gptkb:acquired_angioedema
|
|
gptkbp:discoveredBy
|
gptkb:Donaldson_and_Evans
|
|
gptkbp:encodedBy
|
gptkb:SERPING1_gene
|
|
gptkbp:firstDescribed
|
1963
|
|
gptkbp:foundIn
|
human plasma
|
|
gptkbp:function
|
inhibits coagulation factors
inhibits complement system
inhibits kallikrein
|
|
gptkbp:halfLife
|
2-5 days
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
C1 esterase inhibitor
|
|
gptkbp:inhibitedBy
|
gptkb:C1r
gptkb:C1s
gptkb:kallikrein
gptkb:factor_XIIa
gptkb:factor_XIa
plasmin
|
|
gptkbp:locatedOnChromosome
|
gptkb:chromosome_11q12-q13.1
|
|
gptkbp:medicalUse
|
treatment of hereditary angioedema
|
|
gptkbp:molecularWeight
|
105 kDa
|
|
gptkbp:OMIM
|
606860
|
|
gptkbp:PDB
|
gptkb:5DU3
|
|
gptkbp:producedBy
|
liver
|
|
gptkbp:regulates
|
gptkb:coagulation_system
gptkb:fibrinolytic_system
contact system
complement classical pathway
|
|
gptkbp:sideEffect
|
nausea
headache
injection site reaction
rash
thromboembolism
hypersensitivity reaction
|
|
gptkbp:structure
|
gptkb:protein
|
|
gptkbp:UniProtID
|
P05155
|
|
gptkbp:usedFor
|
acute treatment of angioedema attacks
prophylaxis of angioedema attacks
|
|
gptkbp:bfsParent
|
gptkb:C1_inhibitor_concentrate
gptkb:Berinert
|
|
gptkbp:bfsLayer
|
7
|