|
gptkbp:instanceOf
|
gptkb:drug
Central nervous system depressant
|
|
gptkbp:broadcastOn
|
Schedule II (US, some)
Schedule III (US, some)
Schedule IV (US, some)
|
|
gptkbp:category
|
gptkb:Anesthetic
Anxiolytic
Anticonvulsant
Euthanasia agent
Lethal injection agent
Sedative-hypnotic
|
|
gptkbp:contraindication
|
gptkb:Porphyria
Severe respiratory insufficiency
History of addiction
|
|
gptkbp:discoveredIn
|
1903
|
|
gptkbp:drugInteraction
|
gptkb:beer
gptkb:Benzodiazepines
gptkb:Opioids
Antihistamines
Monoamine oxidase inhibitors
|
|
gptkbp:example
|
gptkb:Pentobarbital
gptkb:Phenobarbital
gptkb:Secobarbital
gptkb:Amobarbital
gptkb:Thiopental
|
|
gptkbp:excretion
|
Urine
|
|
gptkbp:firstSynthesized
|
gptkb:Emil_Fischer
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
Barbiturates
|
|
gptkbp:legalStatus
|
Controlled substance
|
|
gptkbp:mechanismOfAction
|
Enhance GABA-A receptor activity
|
|
gptkbp:metabolism
|
Liver
|
|
gptkbp:overdoseTreatment
|
gptkb:Activated_charcoal
Supportive care
Alkalinization of urine
|
|
gptkbp:replacedBy
|
gptkb:Benzodiazepines
|
|
gptkbp:riskFactor
|
Addiction
Tolerance
Withdrawal syndrome
|
|
gptkbp:routeOfAdministration
|
gptkb:Oral
Rectal
Intramuscular
Intravenous
|
|
gptkbp:sideEffect
|
gptkb:Coma
Dependence
Drowsiness
Respiratory depression
Death (in overdose)
|
|
gptkbp:usedFor
|
gptkb:Anesthesia
Sedation
Epilepsy treatment
Anxiety treatment
Insomnia treatment
|
|
gptkbp:bfsParent
|
gptkb:Benzodiazepines
|
|
gptkbp:bfsLayer
|
6
|