Chlordiazepoxide

GPTKB entity

Statements (54)
Predicate Object
gptkbp:instanceOf gptkb:drug
benzodiazepine
gptkbp:ATCCode N05BA02
gptkbp:brand gptkb:Librium
gptkbp:CASNumber 58-25-3
gptkbp:chemicalClass 1,4-benzodiazepine
gptkbp:contraindication gptkb:myasthenia_gravis
severe respiratory insufficiency
sleep apnea syndrome
severe hepatic insufficiency
gptkbp:developedBy gptkb:Hoffmann-La_Roche
gptkbp:discoveredBy gptkb:Leo_Sternbach
gptkbp:discoveredIn 1957
gptkbp:eliminationHalfLife 5-30 hours
gptkbp:excretion renal
gptkbp:hasMolecularFormula C16H14ClN3O
https://www.w3.org/2000/01/rdf-schema#label Chlordiazepoxide
gptkbp:IUPACName gptkb:7-chloro-2-methylamino-5-phenyl-3H-1,4-benzodiazepin-4-one
gptkbp:KEGGID D00297
gptkbp:legalStatus gptkb:Schedule_IV
prescription only
gptkbp:legalStatusAU S4
gptkbp:legalStatusCA gptkb:Schedule_IV
gptkbp:legalStatusUK Class C
gptkbp:marketedAs 1960
gptkbp:mechanismOfAction GABA-A receptor positive allosteric modulator
gptkbp:MedlinePlusID a682078
gptkbp:meltingPoint 232-233°C
gptkbp:metabolism gptkb:desmethylchlordiazepoxide
gptkb:nordiazepam
gptkb:oxazepam
demoxepam
gptkbp:pregnancyCategory C
D (US)
gptkbp:proteinBinding 96%
gptkbp:PubChem_CID 2726
CHEMBL651
2624
DB00475
gptkbp:routeOfAdministration oral
intramuscular
intravenous
gptkbp:sideEffect confusion
drowsiness
ataxia
dependence
gptkbp:solubility slightly soluble in water
gptkbp:UNII S8VZ499Y41
gptkbp:usedFor gptkb:alcohol_withdrawal_syndrome
anxiety disorders
preoperative sedation
gptkbp:bfsParent gptkb:Benzodiazepines
gptkb:D07917
gptkbp:bfsLayer 6