Statements (46)
| Predicate | Object |
|---|---|
| gptkbp:instanceOf |
gptkb:anatomical_structure
biological barrier |
| gptkbp:abbreviation |
gptkb:BBB
|
| gptkbp:composedOf |
endothelial cells
pericytes astrocyte end-feet |
| gptkbp:discoveredBy |
gptkb:Max_Lewandowsky
|
| gptkbp:discoveredIn |
1900
|
| gptkbp:function |
protects brain from pathogens
regulates passage of substances from blood to brain |
| gptkbp:GO_term |
GO:0001666
|
| gptkbp:hasPart |
basement membrane
tight junctions |
| gptkbp:hasUMLSID |
C0005779
|
| gptkbp:hasWikipediaPage |
https://en.wikipedia.org/wiki/Blood%E2%80%93brain_barrier
|
| https://www.w3.org/2000/01/rdf-schema#label |
Blood-brain barrier
|
| gptkbp:impermeableTo |
large molecules
many drugs most pathogens |
| gptkbp:interruptedBy |
gptkb:trauma
radiation therapy infection hypertension inflammation certain drugs |
| gptkbp:locatedIn |
central nervous system
|
| gptkbp:MeSH_ID |
D001808
|
| gptkbp:permeableTo |
gptkb:water
oxygen carbon dioxide glucose lipid-soluble molecules |
| gptkbp:regulates |
ion homeostasis in brain
immune cell entry to brain neurotransmitter levels |
| gptkbp:relatedTo |
gptkb:Alzheimer's_disease
gptkb:Parkinson's_disease stroke multiple sclerosis neurodegenerative diseases brain tumors |
| gptkbp:studiedIn |
gptkb:pharmacy
neurology neuroscience |
| gptkbp:bfsParent |
gptkb:Benzodiazepines
|
| gptkbp:bfsLayer |
6
|