|
gptkbp:instanceOf
|
gptkb:gene
|
|
gptkbp:alsoKnownAs
|
gptkb:CD317
gptkb:tetherin
|
|
gptkbp:alternativeSplicing
|
yes
|
|
gptkbp:associatedWith
|
gptkb:HIV/AIDS
viral infections
HIV-1 restriction
immune response to viral infection
|
|
gptkbp:chromosomeArm
|
gptkb:19p13.2
|
|
gptkbp:discoveredBy
|
gptkb:Ishikawa_et_al.
|
|
gptkbp:encodes
|
bone marrow stromal antigen 2
|
|
gptkbp:Entrez_Gene_ID
|
684
ENSG00000130303
|
|
gptkbp:expressedIn
|
gptkb:hepatocytes
endothelial cells
monocytes
plasma cells
|
|
gptkbp:firstDescribed
|
1995
|
|
gptkbp:function
|
inhibits release of enveloped viruses
involved in innate immune response
|
|
gptkbp:geneType
|
protein-coding
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
BST2 gene
|
|
gptkbp:interactsWith
|
gptkb:interferon-gamma
gptkb:interferon-beta
gptkb:interferon-alpha
APOBEC3G
HIV-1 Vpu protein
|
|
gptkbp:length
|
180 amino acids
|
|
gptkbp:locatedOnChromosome
|
gptkb:chromosome_19
|
|
gptkbp:location
|
gptkb:plasma_membrane
endosomal membrane
|
|
gptkbp:molecularWeight
|
~30 kDa
|
|
gptkbp:mutationAssociatedWith
|
can affect viral restriction
|
|
gptkbp:OMIM
|
610593
|
|
gptkbp:organism
|
gptkb:Homo_sapiens
|
|
gptkbp:orthologInMouse
|
Bst2
|
|
gptkbp:pathway
|
innate immune system
antiviral mechanism by IFN-stimulated genes
|
|
gptkbp:postTranslationalModification
|
glycosylation
ubiquitination
|
|
gptkbp:product
|
type II transmembrane protein
BST2 protein
|
|
gptkbp:proteinFamily
|
gptkb:CD_molecules
tetherin family
|
|
gptkbp:regulates
|
upregulated by interferon
|
|
gptkbp:structure
|
contains coiled-coil domain
contains GPI anchor
|
|
gptkbp:UniProtID
|
Q10588
|
|
gptkbp:bfsParent
|
gptkb:CD317
|
|
gptkbp:bfsLayer
|
8
|