Statements (51)
| Predicate | Object |
|---|---|
| gptkbp:instanceOf |
gptkb:protein
|
| gptkbp:alternativeName |
ARNTL protein
Brain and muscle ARNT-like protein-1 |
| gptkbp:binds |
E-box elements in DNA
|
| gptkbp:domain |
transactivation domain
PAS domain basic helix-loop-helix (bHLH) |
| gptkbp:encodedBy |
ARNTL gene
|
| gptkbp:Entrez_Gene_ID |
406 (human)
|
| gptkbp:expressedIn |
gptkb:suprachiasmatic_nucleus
peripheral tissues |
| gptkbp:firstDescribed |
1997
|
| gptkbp:formsHeterodimerWith |
gptkb:CLOCK_protein
NPAS2 protein |
| gptkbp:function |
core component of circadian clock
|
| https://www.w3.org/2000/01/rdf-schema#label |
BMAL1 protein (in mammals)
|
| gptkbp:interactsWith |
gptkb:SIRT1
gptkb:CBP_(CREB-binding_protein) PER2 protein CRY1 protein |
| gptkbp:involvedIn |
aging
regulation of cell cycle regulation of metabolism regulation of immune response regulation of sleep-wake cycles |
| gptkbp:knockoutPhenotype |
arrhythmicity in mice
|
| gptkbp:locale |
gptkb:nucleus
gptkb:cytoplasm |
| gptkbp:locatedOnChromosome |
gptkb:chromosome_11_(human)
|
| gptkbp:molecularWeight |
~69 kDa
|
| gptkbp:mutationAssociatedWith |
loss of circadian rhythmicity
|
| gptkbp:OMIM |
602550
|
| gptkbp:orthologInMouse |
Arntl
|
| gptkbp:PDB |
4F3L
|
| gptkbp:postTranslationalModification |
phosphorylation
ubiquitination acetylation |
| gptkbp:regulates |
gptkb:bHLH-PAS
gptkb:REV-ERBα lipid metabolism glucose homeostasis CRY genes PER genes RORα blood pressure rhythms transcription of circadian genes |
| gptkbp:requires |
maintenance of circadian rhythms
normal locomotor activity rhythms |
| gptkbp:UniProtID |
O00327 (human)
|
| gptkbp:bfsParent |
gptkb:CYCLE_protein
|
| gptkbp:bfsLayer |
8
|