|
gptkbp:instanceOf
|
gptkb:protein
|
|
gptkbp:alternativeName
|
gptkb:BLyS
gptkb:TALL-1
gptkb:TNFSF13B
zTNF4
|
|
gptkbp:cleavedForm
|
gptkb:soluble_BAFF
|
|
gptkbp:discoveredBy
|
1999
|
|
gptkbp:encodedBy
|
gptkb:TNFSF13B_gene
|
|
gptkbp:expressedIn
|
immune system
dendritic cells
stromal cells
monocytes
neutrophils
|
|
gptkbp:fullName
|
gptkb:B-cell_activating_factor
|
|
gptkbp:function
|
stimulates B cell proliferation
promotes B cell survival
regulates B cell development
|
|
gptkbp:gene
|
gptkb:TNFSF13B
|
|
gptkbp:GO
|
gptkb:GO:0006955_(immune_response)
gptkb:GO:0030098_(B_cell_proliferation)
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
BAFF
|
|
gptkbp:inhibitionLeadsTo
|
B cell deficiency
|
|
gptkbp:involves
|
gptkb:systemic_lupus_erythematosus
multiple sclerosis
autoimmune diseases
rheumatoid arthritis
|
|
gptkbp:length
|
285 amino acids (precursor)
|
|
gptkbp:locatedOnChromosome
|
gptkb:13q32-q34_(human)
|
|
gptkbp:memberOf
|
gptkb:tumor_necrosis_factor_(TNF)_ligand_family
|
|
gptkbp:molecularWeight
|
32 kDa (precursor)
|
|
gptkbp:OMIM
|
gptkb:603969
|
|
gptkbp:orthologIn
|
gptkb:APRIL
gptkb:Mus_musculus
gptkb:Rattus_norvegicus
|
|
gptkbp:overexpressedIn
|
autoimmunity
B cell hyperplasia
|
|
gptkbp:PDB
|
1OQE
|
|
gptkbp:recipient
|
gptkb:TACI
gptkb:BCMA
gptkb:BAFF-R
|
|
gptkbp:regulates
|
B cell maturation
B cell homeostasis
immunoglobulin production
|
|
gptkbp:species
|
gptkb:Homo_sapiens
|
|
gptkbp:structure
|
type II transmembrane protein
|
|
gptkbp:target
|
gptkb:atacicept
gptkb:belimumab
gptkb:tabalumab
|
|
gptkbp:UniProtID
|
gptkb:Q9Y275
|
|
gptkbp:bfsParent
|
gptkb:BCMA
|
|
gptkbp:bfsLayer
|
6
|