|
gptkbp:instanceOf
|
gptkb:protein
|
|
gptkbp:alternativeName
|
gptkb:CD269
gptkb:Tumor_necrosis_factor_receptor_superfamily_member_17
|
|
gptkbp:associatedWith
|
autoimmune diseases
immunodeficiency
|
|
gptkbp:binds
|
gptkb:APRIL
gptkb:BAFF
|
|
gptkbp:cellSurfaceMarker
|
yes
|
|
gptkbp:discoveredBy
|
E. Thompson et al.
|
|
gptkbp:encodedBy
|
gptkb:TNFRSF17_gene
|
|
gptkbp:expressedIn
|
gptkb:B_lymphocytes
plasma cells
|
|
gptkbp:firstDescribed
|
1992
|
|
gptkbp:fullName
|
gptkb:B-cell_maturation_antigen
|
|
gptkbp:function
|
regulation of B cell maturation
regulation of B cell survival
|
|
gptkbp:gene
|
gptkb:TNFRSF17
|
|
gptkbp:HGNC_ID
|
11910
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
BCMA
|
|
gptkbp:locatedOnChromosome
|
gptkb:16p13.13
|
|
gptkbp:memberOf
|
gptkb:tumor_necrosis_factor_receptor_superfamily
|
|
gptkbp:molecularWeight
|
20 kDa
|
|
gptkbp:OMIM
|
gptkb:603972
|
|
gptkbp:significance
|
multiple myeloma
|
|
gptkbp:structure
|
single-pass type I membrane protein
|
|
gptkbp:target
|
gene therapy
antibody-drug conjugates
bispecific antibodies
|
|
gptkbp:therapeuticArea
|
relapsed/refractory multiple myeloma
|
|
gptkbp:UniProtID
|
gptkb:Q02223
|
|
gptkbp:bfsParent
|
gptkb:gene_therapy
|
|
gptkbp:bfsLayer
|
5
|