Anaphase-promoting complex

GPTKB entity

Predicate	Object
gptkbp:instanceOf	gptkb:protein E3 ubiquitin ligase
gptkbp:alsoKnownAs	gptkb:APC/C
gptkbp:component	gptkb:APC1 gptkb:APC10 gptkb:APC2 gptkb:APC4 gptkb:APC5 gptkb:APC7 gptkb:APC9 gptkb:CDC20 APC11 APC3 (CDC27) APC6 (CDC16) APC8 (CDC23) CDH1 (FZR1)
gptkbp:discoveredIn	1995
gptkbp:EC_number	2.3.2.27
gptkbp:function	regulation of cell cycle ubiquitination of target proteins triggers transition from metaphase to anaphase
gptkbp:GO_term	GO:0005680
gptkbp:hasPart	TPR domain RING-finger domain
https://www.w3.org/2000/01/rdf-schema#label	Anaphase-promoting complex
gptkbp:inhibitedBy	spindle assembly checkpoint
gptkbp:location	gptkb:nucleus gptkb:cytoplasm
gptkbp:OMIM	608473
gptkbp:PDB	4UI9
gptkbp:regulates	gptkb:CDC20 gptkb:CDH1 gptkb:BUBR1 gptkb:MAD2
gptkbp:relatedTo	cell division meiosis mitosis proteolysis
gptkbp:requires	chromosome segregation exit from mitosis
gptkbp:species	gptkb:Mus_musculus gptkb:Saccharomyces_cerevisiae gptkb:Homo_sapiens
gptkbp:substrate	gptkb:cyclin_B gptkb:securin aurora kinases geminin
gptkbp:UniProtID	Q9UJX2
gptkbp:bfsParent	gptkb:APC10 gptkb:APC6 gptkb:Anaphase
gptkbp:bfsLayer	7