Amyotrophic Lateral Sclerosis

URI: https://gptkb.org/entity/Amyotrophic_Lateral_Sclerosis
GPTKB entity
Statements (51)
Predicate Object
gptkbp:instanceOf gptkb:disease
neurodegenerative disease
motor neuron disease
gptkbp:abbreviation gptkb:ALS
gptkbp:affects adults
motor neurons
men more than women
gptkbp:alsoKnownAs gptkb:Lou_Gehrig's_disease
gptkbp:associatedWith gptkb:C9orf72
gptkb:FUS
gptkb:SOD1
gptkb:TARDBP
gptkbp:averageSurvival 2 to 5 years after diagnosis
gptkbp:cause unknown
gptkbp:diagnosedBy MRI
clinical examination
electromyography
nerve conduction study
gptkbp:field neurology
gptkbp:firstDescribed gptkb:Jean-Martin_Charcot
1869
https://www.w3.org/2000/01/rdf-schema#label Amyotrophic Lateral Sclerosis
gptkbp:ICD-10_code G12.2
gptkbp:incidence 1 to 2 per 100,000 people per year
gptkbp:MeSH_ID D000690
gptkbp:namedAfter gptkb:Lou_Gehrig
gptkbp:OMIM 105400
gptkbp:onset adulthood
gptkbp:prevalence 2 to 3 per 100,000 people
gptkbp:prognosis progressive
fatal
gptkbp:riskFactor age
family history
genetic disorder
male sex
gptkbp:subspecies gptkb:familial_ALS
gptkb:sporadic_ALS
gptkbp:symptom difficulty breathing
difficulty speaking
difficulty swallowing
muscle atrophy
muscle weakness
gptkbp:treatment gptkb:edaravone
gptkb:riluzole
supportive care
physical therapy
speech therapy
ventilatory support
gptkbp:bfsParent gptkb:FUS
gptkb:ALS
gptkbp:bfsLayer 5