AMP-activated protein kinase family
GPTKB entity
Statements (52)
| Predicate | Object |
|---|---|
| gptkbp:instanceOf |
gptkb:protein
|
| gptkbp:activatedBy |
gptkb:AICAR
gptkb:metformin gptkb:AMP gptkb:ADP exercise |
| gptkbp:alsoKnownAs |
AMPK family
|
| gptkbp:discoveredBy |
gptkb:D._Grahame_Hardie
|
| gptkbp:EC_number |
2.7.11.31
|
| gptkbp:foundIn |
eukaryotes
|
| gptkbp:function |
regulation of cellular energy homeostasis
|
| gptkbp:gene |
gptkb:PRKAA1
gptkb:PRKAA2 gptkb:PRKAB1 gptkb:PRKAB2 gptkb:PRKAG1 gptkb:PRKAG2 gptkb:PRKAG3 |
| https://www.w3.org/2000/01/rdf-schema#label |
AMP-activated protein kinase family
|
| gptkbp:inhibitedBy |
gptkb:ATP
gptkb:compound_C |
| gptkbp:involvedIn |
cancer research
obesity research cardiovascular disease research type 2 diabetes research |
| gptkbp:member |
AMP-activated protein kinase beta subunit
AMP-activated protein kinase gamma subunit AMP-activated protein kinase alpha subunit |
| gptkbp:orthologIn |
gptkb:plant_SnRK1
gptkb:yeast_SNF1 |
| gptkbp:phosphorylates |
gptkb:CaMKKβ
gptkb:LKB1 Thr172 |
| gptkbp:regulates |
gptkb:mTOR_pathway
cell proliferation gene expression lipid metabolism cell growth glycogen metabolism mitochondrial biogenesis |
| gptkbp:relatedTo |
SNF1 protein kinase family
|
| gptkbp:role |
glucose uptake
autophagy regulation fatty acid oxidation metabolic stress response inhibition of protein synthesis |
| gptkbp:subunit |
heterotrimeric complex
alpha catalytic subunit beta regulatory subunit gamma regulatory subunit |
| gptkbp:bfsParent |
gptkb:Prkaa1
|
| gptkbp:bfsLayer |
8
|