Statements (51)
| Predicate | Object |
|---|---|
| gptkbp:instanceOf |
gptkb:protein
|
| gptkbp:alsoKnownAs |
ATP-binding cassette sub-family C transporters
|
| gptkbp:associatedWith |
multidrug resistance
cystic fibrosis (CFTR) |
| gptkbp:exampleGene |
gptkb:ABCC1
gptkb:ABCC2 ABCC7 (CFTR) |
| gptkbp:foundIn |
humans
eukaryotes |
| gptkbp:function |
transmembrane transport of various molecules
ATP-dependent transport |
| https://www.w3.org/2000/01/rdf-schema#label |
ABCC family transporters
|
| gptkbp:includes |
gptkb:MRP1
gptkb:MRP2 gptkb:CFTR gptkb:MRP7 MRP3 MRP4 MRP5 MRP6 MRP8 MRP9 |
| gptkbp:locatedOnChromosome |
various chromosomes
|
| gptkbp:memberOf |
ABC transporter superfamily
|
| gptkbp:numberOfMembers |
at least 12 in humans
|
| gptkbp:OMIM |
601107 (ABCC2)
601443 (ABCC1) 602421 (ABCC7/CFTR) |
| gptkbp:proteinFamily |
gptkb:ABCC
ABC_C |
| gptkbp:regulates |
histone modification
transcriptional regulation |
| gptkbp:relatedTo |
gptkb:ABC_transporter_family
ABCA family ABCB family ABCD family ABCE family ABCF family ABCG family |
| gptkbp:significance |
hereditary diseases
drug resistance in cancer |
| gptkbp:structure |
two nucleotide-binding domains
two transmembrane domains |
| gptkbp:transportSubstrates |
drugs
bile salts cyclic nucleotides glutathione conjugates organic anions chloride ions (CFTR) |
| gptkbp:bfsParent |
gptkb:YCF1
|
| gptkbp:bfsLayer |
7
|