|
gptkbp:instanceOf
|
gptkb:protein
|
|
gptkbp:activeSiteResidue
|
gptkb:His41
Cys145
|
|
gptkbp:alsoKnownAs
|
gptkb:Mpro
main protease
|
|
gptkbp:catalyticDyad
|
Cys145-His41
|
|
gptkbp:cleavage
|
11 sites in viral polyprotein
|
|
gptkbp:conservedIn
|
high among coronaviruses
|
|
gptkbp:crystalStructureAvailable
|
yes
|
|
gptkbp:EC_number
|
3.4.22.69
|
|
gptkbp:encodedBy
|
coronavirus genome
|
|
gptkbp:firstDescribed
|
2003 (SARS-CoV)
|
|
gptkbp:foundIn
|
coronaviruses
|
|
gptkbp:function
|
cleaves viral polyproteins
|
|
gptkbp:gene
|
gptkb:nsp5
|
|
gptkbp:homodimer
|
yes
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
3C-like protease
|
|
gptkbp:inhibitedBy
|
gptkb:nirmatrelvir
gptkb:GC376
gptkb:boceprevir
gptkb:disulfiram
PF-00835231
PF-07321332 (nirmatrelvir)
alpha-ketoamides
ebselen
|
|
gptkbp:inhibitorDevelopment
|
covalent inhibitors
non-covalent inhibitors
peptidomimetics
|
|
gptkbp:length
|
306 (SARS-CoV-2)
|
|
gptkbp:locatedOnChromosome
|
ORF1ab
|
|
gptkbp:molecularWeight
|
33.8 kDa
|
|
gptkbp:PDB
|
gptkb:6LU7
|
|
gptkbp:potentialForBroadSpectrumInhibitors
|
yes
|
|
gptkbp:presentIn
|
gptkb:COVID-19
gptkb:MERS-CoV
gptkb:SARS-CoV
gptkb:HCoV-229E
gptkb:HCoV-HKU1
gptkb:HCoV-NL63
gptkb:HCoV-OC43
|
|
gptkbp:relatedTo
|
picornavirus 3C protease
|
|
gptkbp:requires
|
coronavirus replication
|
|
gptkbp:roleInLifeCycle
|
processes polyproteins pp1a and pp1ab
|
|
gptkbp:structureType
|
gptkb:cysteine_protease
|
|
gptkbp:subcellularLocation
|
gptkb:cytoplasm
|
|
gptkbp:substrateRecognition
|
Leu-Gln↓(Ser,Ala,Gly)
|
|
gptkbp:target
|
antiviral drug development
|
|
gptkbp:targetOfDrug
|
gptkb:COVID-19
|
|
gptkbp:usedIn
|
antiviral screening assays
|
|
gptkbp:bfsParent
|
gptkb:3LU6
gptkb:3CLpro
|
|
gptkbp:bfsLayer
|
8
|