1,25-dihydroxyvitamin D3

URI: https://gptkb.org/entity/1,25-dihydroxyvitamin_D3

GPTKB entity

Predicate	Object
gptkbp:instanceOf	gptkb:secosteroid_hormone gptkb:vitamin_D_metabolite
gptkbp:approvedDrugIn	gptkb:United_States
gptkbp:ATCCode	A11CC04
gptkbp:biosynthesized_from	gptkb:vitamin_A gptkb:kidney
gptkbp:CASNumber	32222-06-3
gptkbp:category	gptkb:secosteroid gptkb:vitamin_D_metabolite gptkb:hormone
gptkbp:chemicalFormula	C27H44O3
gptkbp:deactivatedIn	gptkb:kidney liver
gptkbp:deactivationEnzyme	24-hydroxylase
gptkbp:discoveredBy	Anthony W. Norman Hector DeLuca
gptkbp:firstDescribed	1971
gptkbp:function	regulation of phosphate homeostasis modulation of immune system regulation of calcium homeostasis bone mineralization promotion of intestinal calcium absorption
gptkbp:IUPACName	(1R,3S,5Z,7E,22E)-9,10-secocholesta-5,7,10(19),22-tetraene-1,3,25-triol
gptkbp:meltingPoint	120-125°C
gptkbp:molecularWeight	416.64 g/mol
gptkbp:otherName	gptkb:calcitriol
gptkbp:predecessor	gptkb:25-hydroxyvitamin_D3
gptkbp:PubChem_CID	5280453 CHEMBL1204
gptkbp:recipient	vitamin D receptor
gptkbp:routeOfAdministration	oral intravenous
gptkbp:solubility	insoluble in water soluble in ethanol soluble in chloroform
gptkbp:UNII	FXC9231JVH
gptkbp:usedFor	gptkb:secondary_hyperparathyroidism hypocalcemia renal osteodystrophy
gptkbp:bfsParent	gptkb:VDR
gptkbp:bfsLayer	7
https://www.w3.org/2000/01/rdf-schema#label	1,25-dihydroxyvitamin D3