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gptkbp:instanceOf
|
biological pathway
|
|
gptkbp:alsoKnownAs
|
gptkb:ornithine_cycle
|
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gptkbp:compatibleWith
|
gptkb:fish
birds
amphibians
reptiles
|
|
gptkbp:energyEfficiency
|
requires ATP
|
|
gptkbp:excretes
|
urea in urine
|
|
gptkbp:firstDescribed
|
gptkb:Hans_Krebs
1932
|
|
gptkbp:function
|
convert ammonia to urea
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
urea cycle in mammals
|
|
gptkbp:importantFor
|
detoxification of ammonia
|
|
gptkbp:location
|
liver
partially in cytosol
partially in mitochondria
|
|
gptkbp:mainEnzyme
|
gptkb:arginase
gptkb:argininosuccinate_lyase
gptkb:argininosuccinate_synthetase
gptkb:carbamoyl_phosphate_synthetase_I
gptkb:ornithine_transcarbamylase
|
|
gptkbp:medium
|
arginine
argininosuccinate
citrulline
ornithine
|
|
gptkbp:product
|
gptkb:urea
fumarate
|
|
gptkbp:regulates
|
N-acetylglutamate
|
|
gptkbp:relatedTo
|
amino acid catabolism
nitrogen metabolism
|
|
gptkbp:species
|
mammals
|
|
gptkbp:substrate
|
gptkb:aspartate
ammonia
|
|
gptkbp:suffersFrom
|
argininosuccinic aciduria
citrullinemia
hyperammonemia
ornithine transcarbamylase deficiency
|
|
gptkbp:bfsParent
|
gptkb:urea
|
|
gptkbp:bfsLayer
|
6
|