|
gptkbp:instanceOf
|
gptkb:protein
|
|
gptkbp:abbreviation
|
gptkb:Tn
|
|
gptkbp:binds
|
calcium ions
|
|
gptkbp:category
|
muscle proteins
|
|
gptkbp:clinicalTrialPhase
|
troponin I test
troponin T test
|
|
gptkbp:compatibleWith
|
smooth muscle
|
|
gptkbp:component
|
muscle thin filament
|
|
gptkbp:composedOf
|
gptkb:troponin_I
gptkb:troponin_C
troponin T
|
|
gptkbp:discoveredIn
|
1965
|
|
gptkbp:EC_number
|
none
|
|
gptkbp:elevatedIn
|
heart attack
|
|
gptkbp:expressedIn
|
striated muscle
|
|
gptkbp:firstDescribed
|
Ebashi et al.
|
|
gptkbp:foundIn
|
gptkb:skeletal_muscle
cardiac muscle
|
|
gptkbp:function
|
regulates muscle contraction
|
|
gptkbp:gene
|
TNNC1
TNNI3
TNNT2
|
|
gptkbp:halfLife
|
2-4 hours (cardiac troponin I)
~120 hours (cardiac troponin T)
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
troponin
|
|
gptkbp:improves
|
myocardial damage
|
|
gptkbp:location
|
sarcomere
|
|
gptkbp:marking
|
cardiac injury
|
|
gptkbp:measures
|
blood plasma
|
|
gptkbp:molecularWeight
|
~77 kDa (complex)
|
|
gptkbp:mutationAssociatedWith
|
gptkb:dilated_cardiomyopathy
gptkb:familial_hypertrophic_cardiomyopathy
restrictive cardiomyopathy
|
|
gptkbp:OMIM
|
191044
|
|
gptkbp:PDB
|
1J1E (structure)
|
|
gptkbp:regulates
|
muscle contraction in response to calcium
|
|
gptkbp:relatedTo
|
gptkb:actin
gptkb:tropomyosin
gptkb:myosin
|
|
gptkbp:role
|
inhibits actin-myosin interaction in absence of calcium
|
|
gptkbp:significance
|
biomarker for cardiac events
|
|
gptkbp:structure
|
heterotrimeric protein
|
|
gptkbp:subunit
|
gptkb:TnT
TnC
TnI
|
|
gptkbp:UniProtID
|
P19429 (TnI), P45379 (TnT), P63316 (TnC)
|
|
gptkbp:usedFor
|
risk stratification in acute coronary syndrome
|
|
gptkbp:usedIn
|
diagnosis of myocardial infarction
|
|
gptkbp:bfsParent
|
gptkb:actin
gptkb:sliding_filament_theory
|
|
gptkbp:bfsLayer
|
7
|