|
gptkbp:instanceOf
|
gptkb:protein
|
|
gptkbp:discoveredBy
|
gptkb:William_Bowman
|
|
gptkbp:discoveredIn
|
1864
|
|
gptkbp:encodedBy
|
MYH genes
|
|
gptkbp:enzymeCommissionNumber
|
EC 3.6.4.1
|
|
gptkbp:form
|
thick filaments
|
|
gptkbp:foundIn
|
gptkb:skeletal_muscle
|
|
gptkbp:function
|
ATPase activity
motor protein
|
|
gptkbp:GO_term
|
GO:0006936 (muscle contraction)
GO:0016459 (myosin complex)
GO:0003779 (actin binding)
|
|
gptkbp:hasPfamID
|
PF00063
|
|
gptkbp:hasType
|
myosin I
myosin II
myosin V
|
|
gptkbp:hasWikipediaPage
|
https://en.wikipedia.org/wiki/Myosin
|
|
gptkbp:headDomainFunction
|
binds actin
hydrolyzes ATP
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
myosin
|
|
gptkbp:interactsWith
|
gptkb:actin
|
|
gptkbp:InterPro
|
IPR001609
|
|
gptkbp:involvedIn
|
muscle contraction
|
|
gptkbp:KEGGID
|
hsa:4627
|
|
gptkbp:locale
|
gptkb:cytoplasm
sarcomere
|
|
gptkbp:molecularWeight
|
~520 kDa (myosin II)
|
|
gptkbp:mutationAssociatedWith
|
deafness
cardiomyopathies
myopathies
|
|
gptkbp:OMIM
|
160760
|
|
gptkbp:PDB
|
1MND
|
|
gptkbp:presentIn
|
animals
fungi
plants
eukaryotes
|
|
gptkbp:Reactome
|
R-HSA-445355
|
|
gptkbp:regulates
|
gptkb:myosin_light_chain_kinase
phosphorylation
calcium ions
|
|
gptkbp:role
|
signal transduction
cell motility
cytokinesis
vesicle transport
|
|
gptkbp:structure
|
head, neck, tail domains
|
|
gptkbp:subunit
|
heavy chain
light chain
|
|
gptkbp:tailDomainFunction
|
dimerization
cargo binding
|
|
gptkbp:UniProtID
|
P12882 (MYH7)
P13533 (MYH9)
|
|
gptkbp:bfsParent
|
gptkb:myosin_heavy_chain_B
gptkb:actin
gptkb:CHEBI:28009
gptkb:Cytoskeleton
gptkb:dynein
gptkb:Skeletal_muscle
gptkb:CHEBI:15765
|
|
gptkbp:bfsLayer
|
7
|