triosephosphate isomerase

URI: https://gptkb.org/entity/triosephosphate_isomerase
GPTKB entity
Statements (33)
Predicate Object
gptkbp:instanceOf gptkb:enzyme
gptkbp:alternativeName gptkb:TIM
phosphotriose isomerase
triose-phosphate isomerase
gptkbp:associatedWith gptkb:triosephosphate_isomerase_deficiency
gptkbp:biologicalProcess isomerase activity
gptkbp:catalyzes interconversion of dihydroxyacetone phosphate and glyceraldehyde 3-phosphate
gptkbp:cofactor none
gptkbp:discoveredBy gptkb:Jakub_Karol_Parnas
gptkbp:EC_number 5.3.1.1
gptkbp:enzymeClassification gptkb:isomerase
gptkbp:first_structure_solved 1975
gptkbp:foldable gptkb:TIM_barrel
gptkbp:foundIn gptkb:gluconeogenesis_pathway
gptkb:glycolysis_pathway
gptkbp:gene gptkb:TPI1
gptkbp:gene_location_(human) gptkb:chromosome_12p13
https://www.w3.org/2000/01/rdf-schema#label triosephosphate isomerase
gptkbp:inhibitedBy phosphoglycolohydroxamate
gptkbp:location gptkb:cytoplasm
gptkbp:molecularWeight ~27 kDa
gptkbp:organism gptkb:Homo_sapiens
gptkb:Bacteria
gptkbp:PDB gptkb:1TIM
gptkbp:product gptkb:glyceraldehyde_3-phosphate
dihydroxyacetone phosphate
gptkbp:requires energy production
gptkbp:structure homodimer
gptkbp:substrate gptkb:glyceraldehyde_3-phosphate
dihydroxyacetone phosphate
gptkbp:UniProtID gptkb:P60174
gptkbp:bfsParent gptkb:TIM_barrel
gptkbp:bfsLayer 8