trastuzumab emtansine

GPTKB entity

Statements (50)
Predicate Object
gptkbp:instanceOf gptkb:monoclonal_antibody
antineoplastic agent
gptkbp:administeredBy gptkb:physician
gptkbp:approvalYear 2013
gptkbp:approvedBy gptkb:FDA
gptkb:EMA
gptkbp:ATCCode L01XC14
gptkbp:biosimilar no (as of 2024)
gptkbp:brand gptkb:Kadcyla
gptkbp:CASNumber 1018448-65-1
gptkbp:chemicalClass monoclonal antibody conjugate
gptkbp:contraindication pregnancy
severe hepatic impairment
hypersensitivity to trastuzumab emtansine
gptkbp:developer gptkb:Genentech
gptkb:Roche
gptkbp:eliminatedIn hepatic
gptkbp:form lyophilized powder for injection
gptkbp:halfLife 3.5-4 days
gptkbp:hasComponent gptkb:DM1_(emtansine)
gptkb:trastuzumab
https://www.w3.org/2000/01/rdf-schema#label trastuzumab emtansine
gptkbp:indication gptkb:HER2-positive_breast_cancer
metastatic breast cancer
early breast cancer (adjuvant)
gptkbp:KEGGID D09913
gptkbp:legalStatus prescription only
patented
gptkbp:mechanismOfAction delivers cytotoxic agent to cancer cells
targets HER2 receptor
gptkbp:MedlinePlusID a613032
gptkbp:metabolism proteolytic enzymes
gptkbp:molecularWeight ~148 kDa
gptkbp:pregnancyCategory D (US)
gptkbp:PubChem_CID gptkb:CHEMBL2108508
DB05919
gptkbp:routeOfAdministration intravenous
gptkbp:RxNorm 1366972
gptkbp:sideEffect gptkb:anemia
nausea
fatigue
peripheral neuropathy
thrombocytopenia
increased liver enzymes
gptkbp:target gptkb:HER2_protein
gptkbp:UNII P8I9DV1DLW
gptkbp:usedFor HER2-positive tumors
gptkbp:usedIn oncology
gptkbp:bfsParent gptkb:DM1_(emtansine)
gptkbp:bfsLayer 7