transferrin receptor

GPTKB entity

Statements (53)
Predicate Object
gptkbp:instanceOf gptkb:protein
gptkbp:alternativeName gptkb:CD71
gptkbp:alternativeSplicing no
gptkbp:associatedWith gptkb:cancer
gptkb:hemochromatosis
iron deficiency anemia
gptkbp:binds gptkb:transferrin
gptkbp:degradedBy gptkb:lysosome
gptkbp:discoveredIn 1970s
gptkbp:domain transferrin receptor domain
gptkbp:EC_number none
gptkbp:encodedBy TFRC gene
gptkbp:expressedHighlyIn gptkb:placenta
erythroid precursors
activated lymphocytes
gptkbp:expressedIn proliferating cells
gptkbp:foundIn gptkb:cell_membrane
gptkbp:function iron uptake
gptkbp:glycosylation yes
gptkbp:GO GO:0004998
gptkbp:hasCytoplasmicDomain yes
gptkbp:hasExtracellularDomain yes
https://www.w3.org/2000/01/rdf-schema#label transferrin receptor
gptkbp:internalizedBy receptor-mediated endocytosis
gptkbp:involvedIn cell growth
immune response
iron transport
gptkbp:ligand apo-transferrin
iron-loaded transferrin
gptkbp:locatedOnChromosome gptkb:3q29
gptkbp:molecularWeight ~85 kDa
gptkbp:mutationAssociatedWith immunodeficiency 46
gptkbp:OMIM 190010
gptkbp:orthologIn gptkb:mouse
right
gptkbp:PDB 1CX8
gptkbp:recycledTo cell surface
gptkbp:role cellular iron homeostasis
gptkbp:signalPeptide no
gptkbp:species gptkb:human
gptkb:mouse
right
gptkbp:structure homodimer
gptkbp:subcellularLocation gptkb:endosome
gptkb:plasma_membrane
gptkbp:target antibody therapies
gptkbp:transmembraneDomains yes
gptkbp:UniProtID P02786
gptkbp:usedAs marker for cell proliferation
gptkbp:bfsParent gptkb:transferrin_protein
gptkb:HFE_protein
gptkb:transferrin
gptkbp:bfsLayer 7