gptkbp:instanceOf
|
gptkb:protein
|
gptkbp:alternativeName
|
gptkb:CD71
|
gptkbp:alternativeSplicing
|
no
|
gptkbp:associatedWith
|
gptkb:cancer
gptkb:hemochromatosis
iron deficiency anemia
|
gptkbp:binds
|
gptkb:transferrin
|
gptkbp:degradedBy
|
gptkb:lysosome
|
gptkbp:discoveredIn
|
1970s
|
gptkbp:domain
|
transferrin receptor domain
|
gptkbp:EC_number
|
none
|
gptkbp:encodedBy
|
TFRC gene
|
gptkbp:expressedHighlyIn
|
gptkb:placenta
erythroid precursors
activated lymphocytes
|
gptkbp:expressedIn
|
proliferating cells
|
gptkbp:foundIn
|
gptkb:cell_membrane
|
gptkbp:function
|
iron uptake
|
gptkbp:glycosylation
|
yes
|
gptkbp:GO
|
GO:0004998
|
gptkbp:hasCytoplasmicDomain
|
yes
|
gptkbp:hasExtracellularDomain
|
yes
|
https://www.w3.org/2000/01/rdf-schema#label
|
transferrin receptor
|
gptkbp:internalizedBy
|
receptor-mediated endocytosis
|
gptkbp:involvedIn
|
cell growth
immune response
iron transport
|
gptkbp:ligand
|
apo-transferrin
iron-loaded transferrin
|
gptkbp:locatedOnChromosome
|
gptkb:3q29
|
gptkbp:molecularWeight
|
~85 kDa
|
gptkbp:mutationAssociatedWith
|
immunodeficiency 46
|
gptkbp:OMIM
|
190010
|
gptkbp:orthologIn
|
gptkb:mouse
right
|
gptkbp:PDB
|
1CX8
|
gptkbp:recycledTo
|
cell surface
|
gptkbp:role
|
cellular iron homeostasis
|
gptkbp:signalPeptide
|
no
|
gptkbp:species
|
gptkb:human
gptkb:mouse
right
|
gptkbp:structure
|
homodimer
|
gptkbp:subcellularLocation
|
gptkb:endosome
gptkb:plasma_membrane
|
gptkbp:target
|
antibody therapies
|
gptkbp:transmembraneDomains
|
yes
|
gptkbp:UniProtID
|
P02786
|
gptkbp:usedAs
|
marker for cell proliferation
|
gptkbp:bfsParent
|
gptkb:transferrin_protein
gptkb:HFE_protein
gptkb:transferrin
|
gptkbp:bfsLayer
|
7
|