telomerase RNA component (TERC)
GPTKB entity
Statements (60)
| Predicate | Object |
|---|---|
| gptkbp:instance_of |
gptkb:RNA_Polymerase
|
| gptkbp:associated_with |
telomere maintenance
telomerase enzyme |
| gptkbp:breeding_range |
3q26.2
|
| gptkbp:clinical_trial |
diagnostic marker for dyskeratosis congenita
prognostic marker in cancer |
| gptkbp:conserved_in |
many eukaryotes
|
| gptkbp:discovery |
gptkb:Carol_Greider
gptkb:Elizabeth_Blackburn gptkb:Jack_Szostak |
| gptkbp:discovery_year |
gptkb:1995
|
| gptkbp:diseases |
gptkb:idiopathic_pulmonary_fibrosis
gptkb:myelodysplastic_syndromes certain cancers aplastic anemia cancer predisposition syndromes associated with dyskeratosis congenita |
| gptkbp:function |
template for telomere elongation
serves as a template for telomere elongation |
| gptkbp:genetic_studies |
point mutations
pulmonary fibrosis deletions insertions dyskeratosis congenita bone marrow failure can lead to premature aging |
| https://www.w3.org/2000/01/rdf-schema#label |
telomerase RNA component (TERC)
|
| gptkbp:interacts_with |
telomerase reverse transcriptase (TERT)
|
| gptkbp:involved_in |
cell proliferation
DNA repair mechanisms cellular senescence tissue regeneration stem cell maintenance telomere length regulation immune response regulation cellular aging processes telomere dynamics germ cell development telomere shortening in aging cancer cell immortality chromosome stability telomerase complex formation telomere lengthening in stem cells |
| gptkbp:is_expressed_in |
high in stem cells
low in differentiated cells highly expressed in stem cells |
| gptkbp:located_in |
gptkb:Atom
|
| gptkbp:location |
gptkb:Atom
|
| gptkbp:promoter |
gptkb:TERC_gene
TERC |
| gptkbp:research_focus |
aging
genetic disorders stem cell biology telomere biology |
| gptkbp:role |
maintains telomere length
|
| gptkbp:role_in_cancer |
telomere shortening in cancer cells
|
| gptkbp:species |
gptkb:Human
|
| gptkbp:targets |
gene therapy approaches
telomerase inhibitors |
| gptkbp:weight |
approximately 450 nucleotides
|