Statements (160)
| Predicate | Object |
|---|---|
| gptkbp:instance_of |
gptkb:Biology
|
| gptkbp:analyzes |
cryo-electron microscopy
|
| gptkbp:can_be |
gptkb:DNA-dependent_DNA_polymerase
gptkb:RNA-dependent_DNA_polymerase multi-subunit complex thermostable error-prone under certain conditions highly specific inhibited by certain chemicals mutated processive |
| gptkbp:can_be_found_in |
eukaryotes
prokaryotes |
| gptkbp:can_be_purified_from |
bacterial cells
|
| gptkbp:components |
DNA replication complex
the transcription machinery |
| gptkbp:composed_of |
multiple subunits
|
| gptkbp:conducts_research_on |
cancer biology
aging research neurobiology |
| gptkbp:discovered_by |
gptkb:Arthur_Kornberg
|
| gptkbp:function |
synthesize RNA from a DNA template
synthesizes RNA from a DNA template synthesize DNA molecules |
| gptkbp:has |
gptkb:sigma_factor
proofreading activity core enzyme |
| gptkbp:has_a |
high fidelity
|
| gptkbp:has_a_focus_on |
biomedical research
genomics research pharmaceutical research biotechnology research synthetic biology research |
| gptkbp:has_role |
transcription elongation
transcription initiation transcription termination |
| gptkbp:has_type |
gptkb:RNA_Polymerase_I
gptkb:RNA_Polymerase_II gptkb:RNA_Polymerase_III |
| https://www.w3.org/2000/01/rdf-schema#label |
RNA Polymerase
|
| gptkbp:initiated_by |
gptkb:azidothymidine_(AZT)
gptkb:alpha-amanitin |
| gptkbp:initiates_transcription_at |
promoter regions
|
| gptkbp:interacts_with |
silencers
enhancers |
| gptkbp:involved_in |
gene expression
|
| gptkbp:is_a_subject_of |
biomedical research
biochemical studies structural biology studies |
| gptkbp:is_affected_by |
mutations
mutations in genes encoding it |
| gptkbp:is_associated_with |
gptkb:DNA_primase
DNA helicase DNA repair pathways. sliding clamp proteins RNA polymerase-associated proteins |
| gptkbp:is_essential_for |
gptkb:developers
gptkb:embryonic_development cell division cellular metabolism developmental processes protein synthesis cellular function cellular differentiation genetic stability cellular communication organismal development DNA synthesis during S phase viral replication in some viruses |
| gptkbp:is_found_in |
all living cells
all living organisms |
| gptkbp:is_influenced_by |
chromatin structure
|
| gptkbp:is_involved_in |
DNA sequencing
RNA splicing DNA damage response DNA repair cell cycle regulation cell differentiation cellular homeostasis cellular metabolism chromatin remodeling immune response signal transduction pathways transcriptional activation transcriptional repression stem cell biology cellular response to stress RNA processing viral replication cellular signaling pathways lagging strand synthesis nucleotide excision repair horizontal gene transfer DNA repair processes RNA stability epigenetic regulation RNA editing cellular repair mechanisms metabolic regulation telomere maintenance immune response regulation cellular aging processes viral replication cycles DNA replication fork progression RNA synthesis in some viruses base excision repair chromosomal replication gene amplification leading strand synthesis mismatch repair chromatin remodeling. transcriptional fidelity chromatin structure maintenance |
| gptkbp:is_regulated_by |
transcription factors
promoter regions various factors |
| gptkbp:is_studied_for |
genetic disorders
cancer research therapeutic applications evolutionary biology insights |
| gptkbp:is_studied_in |
molecular biology
evolutionary biology antiviral strategies |
| gptkbp:is_used_in |
gptkb:gene_therapy
gptkb:polymerase_chain_reaction_(PCR) genetic engineering forensic analysis PCR techniques |
| gptkbp:key_player |
transcription regulation
transcriptional regulation cellular replication machinery |
| gptkbp:location |
found in the cytoplasm of prokaryotic cells
found in the nucleus of eukaryotic cells |
| gptkbp:produces |
gptkb:transfer_RNA_(t_RNA)
messenger RNA (m RNA) ribosomal RNA (r RNA) |
| gptkbp:replaces |
gptkb:Biology
eukaryotes |
| gptkbp:requires |
transcription factors
nucleotide triphosphates template strand DNA template nucleotide substrates |
| gptkbp:role |
replication of DNA
catalyzes the transcription process |
| gptkbp:scientific_classification |
different families
one main type in prokaryotes three main types in eukaryotes |
| gptkbp:structure |
composed of multiple subunits
|
| gptkbp:targets |
antibiotics
pharmaceutical development antiviral drugs cancer therapies gene therapy approaches |
| gptkbp:terminates_transcription_at |
terminator sequences
|
| gptkbp:type |
transcription enzyme
|
| gptkbp:was_a_catalyst_for |
the transcription process
|
| gptkbp:was_a_factor_in |
transcription fidelity
|
| gptkbp:bfsParent |
gptkb:DNA
|
| gptkbp:bfsLayer |
3
|