Statements (62)
| Predicate | Object |
|---|---|
| gptkbp:instance_of |
gptkb:DNA
|
| gptkbp:associated_with |
age-related diseases
cognitive decline metabolic disorders increased cancer risk chronic inflammation telomere maintenance telomere dysfunction immune system function reproductive aging stem cell renewal short telomere syndrome |
| gptkbp:clinical_trial |
biomarker for aging-related diseases
|
| gptkbp:conserved_in |
vertebrates
|
| gptkbp:discovery_year |
gptkb:1997
|
| gptkbp:disorder_association |
pulmonary fibrosis
certain cancers aplastic anemia dyskeratosis congenita |
| gptkbp:expression_level |
decreases with age
|
| gptkbp:function |
telomere elongation
encodes a component of the telomerase enzyme |
| gptkbp:genetic_diversity |
polymorphisms identified
|
| gptkbp:genetic_studies |
telomere shortening
|
| https://www.w3.org/2000/01/rdf-schema#label |
TERC gene
|
| gptkbp:influences |
cell proliferation
cellular homeostasis cellular senescence genomic stability telomere dynamics |
| gptkbp:interacts_with |
TERT protein
|
| gptkbp:involved_in |
cellular aging
cellular differentiation chromosome stability telomerase activity regulation telomere shortening diseases |
| gptkbp:is_expressed_in |
gptkb:Cell
varies in different tissues tissue-specific |
| gptkbp:is_linked_to |
genetic disorders
chronic diseases genetic counseling genetic predisposition to diseases telomere attrition telomere-related pathologies |
| gptkbp:is_recognized_by |
human genome project
|
| gptkbp:is_studied_for |
therapeutic interventions
aging research therapeutic targets |
| gptkbp:is_studied_in |
cancer research
biomedical research regenerative medicine |
| gptkbp:known_as |
gptkb:telomerase_RNA_component
|
| gptkbp:located_in |
human chromosome 3
|
| gptkbp:orthologs |
found in many eukaryotes
|
| gptkbp:regulatory_compliance |
influenced by cellular stress
|
| gptkbp:related_to |
telomerase reverse transcriptase (TERT)
|
| gptkbp:research_areas |
molecular genetics
|
| gptkbp:research_focus |
telomere lengthening therapies
|
| gptkbp:research_importance |
telomere biology
|
| gptkbp:seed_dispersal |
non-coding RNA
|
| gptkbp:transcription_location |
gptkb:Atom
|