Statements (22)
| Predicate | Object |
|---|---|
| gptkbp:instanceOf |
chromosomal band
|
| gptkbp:affects |
hematopoietic stem cells
|
| gptkbp:associatedWith |
gptkb:acute_myeloid_leukemia
|
| gptkbp:chromosomesInvolved |
chromosome 21
chromosome 8 |
| gptkbp:commonIn |
children
young adults |
| gptkbp:cytogeneticNotation |
gptkb:t(8;21)(q22;q22)
|
| gptkbp:detects |
gptkb:FISH
gptkb:RT-PCR karyotyping |
| gptkbp:firstDescribed |
1973
|
| gptkbp:formsFusionGeneWith |
gptkb:RUNX1-RUNX1T1
|
| gptkbp:frequencyInAML |
5-10%
|
| gptkbp:fusionGeneProduct |
gptkb:AML1-ETO
|
| https://www.w3.org/2000/01/rdf-schema#label |
t(8;21) translocation
|
| gptkbp:mayCoexistWith |
KIT mutations
|
| gptkbp:prognosis |
favorable
|
| gptkbp:therapyResponse |
good response to chemotherapy
|
| gptkbp:WHOClassification |
AML with recurrent genetic abnormalities
|
| gptkbp:bfsParent |
gptkb:acute_myeloid_leukemia
|
| gptkbp:bfsLayer |
5
|