Statements (22)
| Predicate | Object |
|---|---|
| gptkbp:instanceOf |
chromosomal band
|
| gptkbp:age |
children
|
| gptkbp:alsoKnownAs |
ETV6-RUNX1 fusion
TEL-AML1 fusion |
| gptkbp:chromosomeInvolved |
gptkb:chromosome_12
chromosome 21 |
| gptkbp:discoveredIn |
1990s
|
| gptkbp:effect |
disrupts normal hematopoiesis
|
| gptkbp:formsFusionGeneWith |
ETV6-RUNX1
|
| gptkbp:foundIn |
leukemia
|
| gptkbp:frequencyInALL |
~25% of childhood B-cell ALL
|
| gptkbp:hasDiagnosticMethod |
gptkb:FISH
gptkb:RT-PCR |
| https://www.w3.org/2000/01/rdf-schema#label |
t(12;21) ETV6-RUNX1
|
| gptkbp:ICD-10_code |
C91.0 (for ALL)
|
| gptkbp:involvedIn |
gptkb:RUNX1
gptkb:ETV6 |
| gptkbp:mechanismOfAction |
fusion of ETV6 gene on 12p13 to RUNX1 gene on 21q22
|
| gptkbp:prognosis |
favorable
|
| gptkbp:significance |
marker for risk stratification in ALL
|
| gptkbp:bfsParent |
gptkb:pre-B-cell_acute_lymphoblastic_leukemia
|
| gptkbp:bfsLayer |
7
|