|
gptkbp:instanceOf
|
gptkb:recombinant_human_growth_hormone
gptkb:peptide
|
|
gptkbp:administeredBy
|
subcutaneous injection
|
|
gptkbp:approvedBy
|
gptkb:FDA
1985
|
|
gptkbp:ATCCode
|
gptkb:H01AC01
|
|
gptkbp:brand
|
gptkb:Genotropin
gptkb:Humatrope
gptkb:Norditropin
gptkb:Nutropin
gptkb:Omnitrope
gptkb:Saizen
gptkb:Zomacton
|
|
gptkbp:CASNumber
|
gptkb:12629-01-5
|
|
gptkbp:category
|
gptkb:recombinant_human_growth_hormone
gptkb:biotechnology
gptkb:peptide_drug
endocrinology
|
|
gptkbp:contraindication
|
active malignancy
acute critical illness
proliferative or severe non-proliferative diabetic retinopathy
|
|
gptkbp:discoveredBy
|
1980s
|
|
gptkbp:eliminationHalfLife
|
2-3 hours (subcutaneous)
20-30 minutes (IV)
|
|
gptkbp:hasMolecularFormula
|
C990H1528N262O300S7
|
|
gptkbp:legalStatus
|
prescription only
|
|
gptkbp:mechanismOfAction
|
stimulates growth, cell reproduction, and cell regeneration
|
|
gptkbp:metabolism
|
gptkb:kidney
liver
|
|
gptkbp:pregnancyCategory
|
C (US)
|
|
gptkbp:producedBy
|
recombinant DNA technology
|
|
gptkbp:proteinSequence
|
identical to endogenous human growth hormone (191 amino acids)
|
|
gptkbp:routeOfAdministration
|
intramuscular
subcutaneous
|
|
gptkbp:sideEffect
|
gptkb:carpal_tunnel_syndrome
edema
joint pain
muscle pain
|
|
gptkbp:UNII
|
QGH3P0U891
|
|
gptkbp:usedFor
|
gptkb:Prader-Willi_syndrome
gptkb:Turner_syndrome
short bowel syndrome
growth hormone deficiency
HIV-associated wasting
chronic renal insufficiency
idiopathic short stature
|
|
gptkbp:bfsParent
|
gptkb:Genotropin
gptkb:Humatrope
gptkb:Norditropin
gptkb:Nutropin
gptkb:Omnitrope
gptkb:Saizen
gptkb:Serostim
gptkb:Tev-Tropin
gptkb:Valtropin
gptkb:Zomacton
|
|
gptkbp:bfsLayer
|
7
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
somatropin
|