Statements (49)
| Predicate | Object |
|---|---|
| gptkbp:instanceOf |
recombinant human growth hormone
peptide |
| gptkbp:administeredBy |
subcutaneous injection
|
| gptkbp:approvedBy |
gptkb:FDA
1985 |
| gptkbp:ATCCode |
gptkb:H01AC01
|
| gptkbp:brand |
gptkb:Genotropin
gptkb:Humatrope gptkb:Norditropin gptkb:Nutropin gptkb:Omnitrope gptkb:Saizen gptkb:Zomacton |
| gptkbp:CASNumber |
gptkb:12629-01-5
|
| gptkbp:category |
gptkb:biotechnology
endocrinology recombinant human growth hormone peptide drug |
| gptkbp:contraindication |
active malignancy
acute critical illness proliferative or severe non-proliferative diabetic retinopathy |
| gptkbp:discoveredBy |
1980s
|
| gptkbp:eliminationHalfLife |
2-3 hours (subcutaneous)
20-30 minutes (IV) |
| gptkbp:hasMolecularFormula |
C990H1528N262O300S7
|
| https://www.w3.org/2000/01/rdf-schema#label |
somatropin
|
| gptkbp:legalStatus |
prescription only
|
| gptkbp:mechanismOfAction |
stimulates growth, cell reproduction, and cell regeneration
|
| gptkbp:metabolism |
gptkb:kidney
liver |
| gptkbp:pregnancyCategory |
C (US)
|
| gptkbp:producedBy |
recombinant DNA technology
|
| gptkbp:proteinSequence |
identical to endogenous human growth hormone (191 amino acids)
|
| gptkbp:routeOfAdministration |
intramuscular
subcutaneous |
| gptkbp:sideEffect |
gptkb:carpal_tunnel_syndrome
edema joint pain muscle pain |
| gptkbp:UNII |
QGH3P0U891
|
| gptkbp:usedFor |
gptkb:Prader-Willi_syndrome
gptkb:Turner_syndrome short bowel syndrome growth hormone deficiency HIV-associated wasting chronic renal insufficiency idiopathic short stature |
| gptkbp:bfsParent |
gptkb:Saizen
|
| gptkbp:bfsLayer |
6
|