Statements (21)
| Predicate | Object |
|---|---|
| gptkbp:instanceOf |
enzyme subunit
|
| gptkbp:associatedWith |
gptkb:pyruvate_dehydrogenase_deficiency
|
| gptkbp:biologicalProcess |
pyruvate dehydrogenase (acetyl-transferring) activity
|
| gptkbp:catalyzes |
oxidative decarboxylation of pyruvate
|
| gptkbp:cofactor |
magnesium ion
thiamine pyrophosphate |
| gptkbp:component |
gptkb:pyruvate_dehydrogenase_complex
|
| gptkbp:enzymeCommissionNumber |
1.2.4.1
|
| gptkbp:gene |
gptkb:PDHB
gptkb:PDHA1 |
| https://www.w3.org/2000/01/rdf-schema#label |
E1 (pyruvate dehydrogenase)
|
| gptkbp:location |
mitochondrial matrix
|
| gptkbp:product |
CO2
hydroxyethyl-TPP intermediate |
| gptkbp:regulates |
dephosphorylation (activation)
phosphorylation (inactivation) |
| gptkbp:substrate |
gptkb:pyruvate
|
| gptkbp:subunit |
heterotetramer (2 alpha, 2 beta)
|
| gptkbp:systematicName |
pyruvate:ferredoxin oxidoreductase (decarboxylating, acetyl-transferring)
|
| gptkbp:bfsParent |
gptkb:pyruvate_dehydrogenase_complex
|
| gptkbp:bfsLayer |
7
|