Creutzfeldt-Jakob disease

URI: https://gptkb.org/entity/Creutzfeldt-Jakob_disease
GPTKB entity
Statements (50)
Predicate Object
gptkbp:instanceOf gptkb:disease
neurodegenerative disease
prion disease
gptkbp:affects humans
gptkbp:alsoKnownAs gptkb:CJD
gptkbp:averageSurvivalAfterOnset 6 months
less than 1 year
gptkbp:category gptkb:disease
neurological disorder
rare disease
gptkbp:causedBy misfolded prion proteins
gptkbp:diagnosedBy gptkb:EEG
MRI
CSF analysis
brain biopsy
gptkbp:firstDescribed gptkb:Alfons_Maria_Jakob
gptkb:Hans_Gerhard_Creutzfeldt
1920
gptkbp:hasEpidemiology 1 case per million people per year
gptkbp:hasNoCure true
gptkbp:hasOrphanetID gptkb:ORPHA399
https://www.w3.org/2000/01/rdf-schema#label Creutzfeldt-Jakob disease
gptkbp:ICD-10_code A81.0
gptkbp:MeSH_ID D003456
gptkbp:namedAfter gptkb:Alfons_Maria_Jakob
gptkb:Hans_Gerhard_Creutzfeldt
gptkbp:OMIM 123400
gptkbp:onset 60 years
gptkbp:prognosis fatal
gptkbp:relatedTo gptkb:Gerstmann-Sträussler-Scheinker_syndrome
gptkb:fatal_familial_insomnia
kuru
gptkbp:riskFactor family history
consumption of contaminated beef (vCJD)
exposure to contaminated medical equipment
gptkbp:symptom gptkb:dementia
memory loss
muscle stiffness
ataxia
personality changes
myoclonus
visual disturbances
speech impairment
gptkbp:transmission hereditary
sporadic
iatrogenic
variant (vCJD)
gptkbp:treatment supportive care
gptkbp:bfsParent gptkb:Kuru
gptkbp:bfsLayer 5