Creutzfeldt-Jakob disease

URI: https://gptkb.org/entity/Creutzfeldt-Jakob_disease

GPTKB entity

Predicate	Object
gptkbp:instanceOf	gptkb:neurodegenerative_disease gptkb:prion_disease gptkb:disease
gptkbp:affects	humans
gptkbp:alsoKnownAs	gptkb:CJD
gptkbp:averageSurvivalAfterOnset	6 months less than 1 year
gptkbp:category	gptkb:neurological_disorder gptkb:disease gptkb:rare_disease
gptkbp:causedBy	misfolded prion proteins
gptkbp:diagnosedBy	gptkb:EEG MRI CSF analysis brain biopsy
gptkbp:firstDescribed	gptkb:Alfons_Maria_Jakob gptkb:Hans_Gerhard_Creutzfeldt 1920
gptkbp:hasEpidemiology	1 case per million people per year
gptkbp:hasNoCure	true
gptkbp:hasOrphanetID	gptkb:ORPHA399
gptkbp:ICD-10_code	A81.0
gptkbp:MeSH_ID	D003456
gptkbp:namedAfter	gptkb:Alfons_Maria_Jakob gptkb:Hans_Gerhard_Creutzfeldt
gptkbp:OMIM	123400
gptkbp:onset	60 years
gptkbp:prognosis	fatal
gptkbp:relatedTo	gptkb:Gerstmann-Sträussler-Scheinker_syndrome gptkb:fatal_familial_insomnia kuru
gptkbp:riskFactor	family history consumption of contaminated beef (vCJD) exposure to contaminated medical equipment
gptkbp:symptom	gptkb:dementia memory loss muscle stiffness ataxia personality changes myoclonus visual disturbances speech impairment
gptkbp:transmission	hereditary sporadic iatrogenic variant (vCJD)
gptkbp:treatment	supportive care
gptkbp:bfsParent	gptkb:UCL_Institute_of_Prion_Diseases gptkb:Kuru
gptkbp:bfsLayer	6
https://www.w3.org/2000/01/rdf-schema#label	Creutzfeldt-Jakob disease