primary biliary cholangitis

URI: https://gptkb.org/entity/primary_biliary_cholangitis
GPTKB entity
Statements (49)
Predicate Object
gptkbp:instanceOf gptkb:liver_disease
autoimmune disease
gptkbp:affectsOrgan liver
gptkbp:alsoKnownAs gptkb:primary_biliary_cirrhosis
gptkbp:associatedWith other autoimmune diseases
gptkbp:cause cirrhosis
liver failure
dry mouth
cholestasis
hyperlipidemia
dry eyes
hyperpigmentation
steatorrhea
malabsorption
gptkbp:characterizedBy destruction of intrahepatic bile ducts
gptkbp:commonIn gptkb:women
gptkbp:complication gptkb:fat-soluble_vitamin_deficiency
gptkb:bone
portal hypertension
gptkbp:diagnosedBy imaging
serology
liver biopsy
liver function tests
antimitochondrial antibodies
elevated alkaline phosphatase
gptkbp:firstDescribed 1851
gptkbp:hasAutoantibody antimitochondrial antibody (AMA)
gptkbp:hasGeneticComponent true
gptkbp:hasNoCure true
https://www.w3.org/2000/01/rdf-schema#label primary biliary cholangitis
gptkbp:ICD-10_code K74.3
gptkbp:MeSH_ID D003972
gptkbp:OMIM 109720
gptkbp:onset 30-60 years
gptkbp:prevalence rare
gptkbp:progression slow
gptkbp:riskFactor family history
middle age
female sex
gptkbp:symptom fatigue
jaundice
pruritus
xanthomas
hepatomegaly
gptkbp:treatment gptkb:obeticholic_acid
gptkb:ursodeoxycholic_acid
liver transplantation
gptkbp:bfsParent gptkb:obeticholic_acid
gptkbp:bfsLayer 6