|
gptkbp:instanceOf
|
antibiotic combination
|
|
gptkbp:ATCCode
|
J01CR05
|
|
gptkbp:brand
|
gptkb:Zosyn
|
|
gptkbp:contains
|
piperacillin
tazobactam
|
|
gptkbp:contraindication
|
penicillin allergy
|
|
gptkbp:discoveredBy
|
1992
|
|
gptkbp:drugClass
|
beta-lactam/beta-lactamase inhibitor
|
|
gptkbp:effect
|
gptkb:Pseudomonas_aeruginosa
gptkb:Bacteria
gptkb:Streptococcus_species
gptkb:Klebsiella_pneumoniae
Staphylococcus aureus (non-MRSA)
|
|
gptkbp:eliminatedIn
|
renal
|
|
gptkbp:excretion
|
urine
bile
|
|
gptkbp:form
|
powder for solution for injection
solution for infusion
|
|
gptkbp:halfLife
|
0.7-1.2 hours
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
piperacillin-tazobactam
|
|
gptkbp:indication
|
gptkb:pneumonia
sepsis
urinary tract infections
intra-abdominal infections
skin and soft tissue infections
gynecological infections
|
|
gptkbp:interactsWith
|
gptkb:methotrexate
gptkb:aminoglycosides
anticoagulants
vancomycin
|
|
gptkbp:legalStatus
|
prescription only
|
|
gptkbp:mechanismOfAction
|
inhibits bacterial cell wall synthesis
inhibits beta-lactamase enzymes
|
|
gptkbp:metabolism
|
minimal hepatic
|
|
gptkbp:notEffectiveAgainst
|
gptkb:MRSA
gptkb:VRE
|
|
gptkbp:pregnancyCategory
|
B (US)
|
|
gptkbp:riskFactor
|
gptkb:Clostridioides_difficile_infection
elevated liver enzymes
neutropenia
thrombocytopenia
|
|
gptkbp:routeOfAdministration
|
intravenous
|
|
gptkbp:sideEffect
|
nausea
diarrhea
rash
allergic reactions
|
|
gptkbp:spectrumOfActivity
|
broad-spectrum
|
|
gptkbp:usedFor
|
bacterial infections
|
|
gptkbp:WHOModelListOfEssentialMedicines
|
true
|
|
gptkbp:bfsParent
|
gptkb:Pseudomonas_aeruginosa
|
|
gptkbp:bfsLayer
|
6
|